Evidence map›Paper›PMID 36213357›Full record

ArticleJACC. CardioOncology2022

Impact of Social Vulnerability on Comorbid Cancer and Cardiovascular Disease Mortality in the United States.

Sarju Ganatra, Sourbha S Dani, Ashish Kumar, Safi U Khan, Rishi Wadhera, Tomas G Neilan, Paaladinesh Thavendiranathan, Ana Barac, Joerg Hermann, Monika Leja and 20 more

Open access · goldAbstract read
In one paragraph

Article in JACC. CardioOncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 78 citations in OpenAlex.

  1. Trial
  2. Examining the Role of the Social Vulnerability Index in the Association between Race/Ethnicity and Breast Cancer Outcomes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  3. Article
  4. Associations Between Neighborhood Social Vulnerability and the Distribution of Rhinologists in the United States.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Article
  5. Article
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  9. Research Priorities and Future Directions in Cardio-Oncology.Current treatment options in oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 2 countries.

Sarju GanatraCardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine, Lahey Hospital & Medical Center, Burlington, Massachusetts, USA.
Sourbha S DaniDivision of Cardiovascular Medicine, Department of Medicine, Lahey Hospital & Medical Center, Burlington, Massachusetts, USA.
Ashish KumarDepartment of Medicine, Cleveland Clinic Akron General, Akron, Ohio, USA.
Safi U KhanDepartment of Cardiovascular Medicine, Houston Methodist, Houston, Texas, USA.
Rishi WadheraRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Tomas G NeilanCardiovascular Imaging Research Center and Cardio-Oncology Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
Paaladinesh ThavendiranathanTed Rogers Program in Cardiotoxicity Prevention, Division of Cardiology and Joint Division of Medical Imaging, Peter Munk Cardiac Center, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Ana BaracCardio-Oncology Program, Department of Cardiology, MedStar Washington Hospital Center, MedStar Heart and Vascular Institute, Washington, District of Columbia, USA.
Joerg HermannCardio-Oncology Program, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Monika LejaCardio-Oncology Program, Department of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Anita DeswalCardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine, MD Anderson Cancer Center, Houston, Texas, USA.
Michael FradleyCardio-Oncology Translational Center of Excellence, Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jennifer E LiuCardiology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Diego SadlerCardio-Oncology Program, Department of Cardiovascular Medicine, Cleveland Clinic Florida, Weston, Florida, USA.
Aarti AsnaniCardio-Oncology Program, Department of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Lauren A BaldassarreCardio-Oncology Program, Department of Cardiovascular Medicine, Yale New Haven Hospital, Yale University, New Haven, Connecticut, USA.
Dipti GuptaCardiology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Eric YangCardio-Oncology Program, Department of Cardiovascular Medicine, University of California-Los Angeles, Los Angeles, California, USA.
Avirup GuhaCardio-Oncology Program, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Sherry-Ann BrownCardio-Oncology Program, Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jennifer StevensCenter for Healthcare Delivery Science, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Salim S HayekCardio-Oncology Program, Department of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Charles PorterCardio-Oncology Program, Department of Cardiovascular Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.
Ankur KalraDepartment of Cardiovascular Medicine, Indiana University, Indianapolis, Indiana, USA.
Suzanne J BaronDivision of Cardiovascular Medicine, Department of Medicine, Lahey Hospital & Medical Center, Burlington, Massachusetts, USA.
Bonnie KyCardio-Oncology Translational Center of Excellence, Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Salim S ViraniHealth Policy and Quality Program, Michael E. DeBakey VA Medical Center, Health Services Research and Development Center of Excellence and Section of Health Services Research, Baylor College of Medicine, Houston, Texas, USA.
Dhruv KaziRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Khurram NasirDepartment of Cardiovascular Medicine, Houston Methodist, Houston, Texas, USA.
Anju NohriaCardio-Oncology Program, Department of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Beth Israel Deaconess Medical Center · USHouston Methodist · USLahey Medical Center · USMemorial Sloan Kettering Cancer Center · USUniversity of Michigan · USUniversity of Pennsylvania · USAugusta University · USBrigham and Women's Hospital · USCleveland Clinic · USCleveland Clinic Florida · USIndiana University – Purdue University Indianapolis · USLahey Hospital and Medical Center · USMassachusetts General Hospital · USMayo Clinic · USMedical College of Wisconsin · USMedStar Washington Hospital Center · USMichael E. DeBakey VA Medical Center · USThe University of Texas MD Anderson Cancer Center · USUniversity Health Network · CAUniversity of California, Los Angeles · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cardiovascular Diseases among Patients with Cancer and Patients living with HIVK24HL150238 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Tomas G Neilan · 2020 to 2026
$883k
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA008748NHLBI NIH HHS K24 HL150238
6 · The paper itself

Abstract

Background: Racial and social disparities exist in outcomes related to cancer and cardiovascular disease (CVD). Objectives: The aim of this cross-sectional study was to study the impact of social vulnerability on mortality attributed to comorbid cancer and CVD. Methods: The Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database (2015-2019) was used to obtain county-level mortality data attributed to cancer, CVD, and comorbid cancer and CVD. County-level social vulnerability index (SVI) data (2014-2018) were obtained from the CDC's Agency for Toxic Substances and Disease Registry. SVI percentiles were generated for each county and aggregated to form SVI quartiles. Age-adjusted mortality rates (AAMRs) were estimated and compared across SVI quartiles to assess the impact of social vulnerability on mortality related to cancer, CVD, and comorbid cancer and CVD. Results: The AAMR for comorbid cancer and CVD was 47.75 (95% CI: 47.66-47.85) per 100,000 person-years, with higher mortality in counties with greater social vulnerability. AAMRs for cancer and CVD were also significantly greater in counties with the highest SVIs. However, the proportional increase in mortality between the highest and lowest SVI counties was greater for comorbid cancer and CVD than for either cancer or CVD alone. Adults <45 years of age, women, Asian and Pacific Islanders, and Hispanics had the highest relative increase in comorbid cancer and CVD mortality between the fourth and first SVI quartiles, without significant urban-rural differences. Conclusions: Comorbid cancer and CVD mortality increased in counties with higher social vulnerability. Improved education, resource allocation, and targeted public health interventions are needed to address inequities in cardio-oncology.

Indexed as

AAMR, age-adjusted mortality ratesCDC, Centers for Disease Control and PreventionCVD, cardiovascular diseasedisparitiesepidemiologyICD, International Classification of Diseasesrisk factorRR, rate ratioSDOH, social determinants of healthSVI, social vulnerability index

Identifiers

PMID36213357
PMCPMC9537091
OpenAlexW4296475187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.