Evidence map›Paper›PMID 36213312›Full record

ArticleBrain communications2022

Improving risk indexes for Alzheimer's disease and related dementias for use in midlife.

Aaron Reuben, Terrie E Moffitt, Wickliffe C Abraham, Antony Ambler, Maxwell L Elliott, Ahmad R Hariri, Honalee Harrington, Sean Hogan, Renate M Houts, David Ireland and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Aaron ReubenDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0001-5713-4913
Terrie E MoffittDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Wickliffe C AbrahamBrain Health Research Centre, Department of Psychology, University of Otago, Dunedin, New Zealand.
Antony AmblerKing's College London, Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, London, UK.ORCID https://orcid.org/0000-0002-7553-3632
Maxwell L ElliottDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0003-1083-6277
Ahmad R HaririDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Honalee HarringtonDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0002-0225-0607
Sean HoganDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0001-8568-3426
Renate M HoutsDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
David IrelandDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Annchen R KnodtDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Joan LeungSchool of Psychology, The University of Auckland, Auckland, New Zealand.
Amber PearsonDepartment of Geography, Environment, and Spatial Sciences, Michigan State University, East Lansing, MI, USA.
Richie PoultonDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Suzanne C PurdyCenter for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Sandhya RamrakhaDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0002-0383-9886
Line J H RasmussenDepartment of Clinical Research, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark.
Karen SugdenDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Peter R ThorneCenter for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Benjamin WilliamsDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Graham WilsonDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Avshalom CaspiDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0003-0082-4600

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Sarah B. Peskoe · 2006 to 2026
$24.6M
STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2M
Quantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6M
Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
Comprehensive portrait of long-term cannabis users: Are they ready for old age?R01AG069939 · NIA · DUKE UNIVERSITY · PI MOFFITT, TERRIE E · 2021 to 2024
$1.3M
Investigating neighborhood-environment contributions to midlife risk for dementiaF32ES034238 · NIEHS · DUKE UNIVERSITY · PI REUBEN, AARON · 2022 to 2024
$181k
Evaluating neurodegenerative risk in middle-aged adults exposed to lead as childrenF31ES029358 · NIEHS · DUKE UNIVERSITY · PI REUBEN, AARON · 2018 to 2020
$113k
Medical Research Council MR/P005918/1NIA NIH HHS P30 AG028716NIA NIH HHS P30 AG034424NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG049789NIA NIH HHS R01 AG069939NIEHS NIH HHS F31 ES029358NIEHS NIH HHS F32 ES034238
6 · The paper itself

Abstract

Knowledge of a person's risk for Alzheimer's disease and related dementias (ADRDs) is required to triage candidates for preventive interventions, surveillance, and treatment trials. ADRD risk indexes exist for this purpose, but each includes only a subset of known risk factors. Information missing from published indexes could improve risk prediction. In the Dunedin Study of a population-representative New Zealand-based birth cohort followed to midlife (

Indexed as

Alzheimer’s diseasedementiamodifiable risk factorspreventive medicinerisk index

Identifiers

PMID36213312
PMCPMC9535507

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.