ArticleFrontiers in physiology2022
Comparison between conduction system pacing and cardiac resynchronization therapy in right bundle branch block patients.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Resynchronisation efficacy of pacing strategies depends on the assessment metric: a computational study.Frontiers in physiology · 2026Article
- Conduction System Pacing Improved Cardiac Functions, Myocardial Work and Functional Capacity in Heart Failure with Reduced Ejection Fraction and Right Bundle Branch Block.Journal of clinical medicine · 2025Article
- Article
- An in silico guide for ventriculo-ventricular delay programming for left bundle branch-optimized cardiac resynchronization therapy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Credibility assessment of in silico clinical trials for medical devices.PLoS computational biology · 2024Review
- Digital twinning of cardiac electrophysiology for congenital heart disease.Journal of the Royal Society, Interface · 2024Article
- Computational Modelling Enabling In Silico Trials for Cardiac Physiologic Pacing.Journal of cardiovascular translational research · 2024Review
- Digital twinning of cardiac electrophysiology for congenital heart disease.bioRxiv : the preprint server for biology · 2023Article
- Conduction System Pacing versus Conventional Biventricular Pacing for Cardiac Resynchronization Therapy: Where Are We Heading?Journal of clinical medicine · 2023Review
- Cardiac Resynchronisation with Conduction System Pacing.Arrhythmia & electrophysiology review · 2023Review
- Recruitment of the cardiac conduction system for optimal resynchronization therapy in failing heart.Frontiers in physiology · 2022Review
- Leadless biventricular left bundle and endocardial lateral wall pacing versus left bundle only pacing in left bundle branch block patients.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
A significant number of right bundle branch block (RBBB) patients receive cardiac resynchronization therapy (CRT), despite lack of evidence for benefit in this patient group. His bundle (HBP) and left bundle pacing (LBP) are novel CRT delivery methods, but their effect on RBBB remains understudied. We aim to compare pacing-induced electrical synchrony during conventional CRT, HBP, and LBP in RBBB patients with different conduction disturbances, and to investigate whether alternative ways of delivering LBP improve response to pacing. We simulated ventricular activation on twenty-four four-chamber heart geometries each including a His-Purkinje system with proximal right bundle branch block (RBBB). We simulated RBBB combined with left anterior and posterior fascicular blocks (LAFB and LPFB). Additionally, RBBB was simulated in the presence of slow conduction velocity (CV) in the myocardium, left ventricular (LV) or right ventricular (RV) His-Purkinje system, and whole His-Purkinje system. Electrical synchrony was measured by the shortest interval to activate 90% of the ventricles (BIVAT-90). Compared to baseline, HBP significantly improved activation times for RBBB alone (BIVAT-90: 66.9 ± 5.5 ms vs. 42.6 ± 3.8 ms,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.