Evidence map›Paper›PMID 36212856›Full record

ArticleFrontiers in microbiology2022

Impact of SARS-CoV-2-specific memory B cells on the immune response after mRNA-based Comirnaty vaccine in seronegative health care workers.

Alejandro Vallejo, Pilar Vizcarra, Adrián Martín-Hondarza, Sandra Gómez-Maldonado, Johannes Haemmerle, Héctor Velasco, José L Casado

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Extending ImmunoSpotVaccines · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alejandro VallejoLaboratory of Immunovirology, Department of Infectious Diseases, Ramon y Cajal Institute for Health Investigation (IRyCIS), University Hospital Ramón y Cajal, Madrid, Spain.
Pilar VizcarraDepartment of Infectious Diseases, Ramon y Cajal Institute for Health Investigation (IRyCIS), University Hospital Ramón y Cajal, Madrid, Spain.
Adrián Martín-HondarzaLaboratory of Immunovirology, Department of Infectious Diseases, Ramon y Cajal Institute for Health Investigation (IRyCIS), University Hospital Ramón y Cajal, Madrid, Spain.
Sandra Gómez-MaldonadoDepartment of Infectious Diseases, Ramon y Cajal Institute for Health Investigation (IRyCIS), University Hospital Ramón y Cajal, Madrid, Spain.
Johannes HaemmerleDepartment of Prevention of Occupational Risks, University Hospital Ramón y Cajal, Madrid, Spain.
Héctor VelascoLaboratory of Immunovirology, Department of Infectious Diseases, Ramon y Cajal Institute for Health Investigation (IRyCIS), University Hospital Ramón y Cajal, Madrid, Spain.
José L CasadoDepartment of Infectious Diseases, Ramon y Cajal Institute for Health Investigation (IRyCIS), University Hospital Ramón y Cajal, Madrid, Spain.
Instituto Cajal · ESHospital Universitario Ramón y Cajal · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To analyze the impact of SARS-COV-2-specific memory B cells (MBC) on the immune response after two doses of mRNA-based Comirnaty COVID-19 vaccine in seronegative health care workers. This study is seeking a rationale for boosting vaccines. Methods: Longitudinal study including 31 seronegative health care workers with undetectable specific MBCs (IgG Results: The level of specific MBCs, and isotypes, in the IgG Conclusion: IgG

Indexed as

immune responseSARS-CoV-2specific memory B cellsT cell responsevaccine

Identifiers

PMID36212856
PMCPMC9535088
OpenAlexW4296991802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.