Evidence map›Paper›PMID 36212530›Full record

ArticleComputational and structural biotechnology journal2022

Identification of mild cognitive impairment subtypes predicting conversion to Alzheimer's disease using multimodal data.

Masataka Kikuchi, Kaori Kobayashi, Sakiko Itoh, Kensaku Kasuga, Akinori Miyashita, Takeshi Ikeuchi, Eiji Yumoto, Yuki Kosaka, Yasuto Fushimi, Toshihiro Takeda and 6 more

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Multi-Modal Deep Clustering Survival Machines for Alzheimer's Disease Subtype Discovery.... IEEE International Conference on Computer Vision workshops. IEEE International Conference on Computer Vision · 2025
    Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Masataka KikuchiDepartment of Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kaori KobayashiDepartment of Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Sakiko ItohDepartment of Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kensaku KasugaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
Akinori MiyashitaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
Takeshi IkeuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
Eiji YumotoBiometrics Research Laboratories, NEC Corporation, Kanagawa, Japan.
Yuki KosakaBiometrics Research Laboratories, NEC Corporation, Kanagawa, Japan.
Yasuto FushimiMedical Solutions Division, NEC Corporation, Tokyo, Japan.
Toshihiro TakedaDepartment of Medical Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Shirou ManabeDepartment of Medical Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Satoshi HattoriDepartment of Biomedical Statistics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Alzheimer's Disease Neuroimaging Initiative
Akihiro NakayaDepartment of Genome Data Science, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
Kenichi KamijoMedical Solutions Division, NEC Corporation, Tokyo, Japan.
Yasushi MatsumuraDepartment of Medical Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
NEC (Japan) · JPThe University of Osaka · JPNiigata University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mild cognitive impairment (MCI) is a high-risk condition for conversion to Alzheimer's disease (AD) dementia. However, individuals with MCI show heterogeneous patterns of pathology and conversion to AD dementia. Thus, detailed subtyping of MCI subjects and accurate prediction of the patients in whom MCI will convert to AD dementia is critical for identifying at-risk populations and the underlying biological features. To this end, we developed a model that simultaneously subtypes MCI subjects and predicts conversion to AD and performed an analysis of the underlying biological characteristics of each subtype. In particular, a heterogeneous mixture learning (HML) method was used to build a decision tree-based model based on multimodal data, including cerebrospinal fluid (CSF) biomarker data, structural magnetic resonance imaging (MRI) data,

Indexed as

Alzheimer’s diseaseDecision treesMild cognitive impairment

Identifiers

PMID36212530
PMCPMC9513733
OpenAlexW4292559781

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.