Evidence map›Paper›PMID 36212193›Full record

ArticleFrontiers in behavioral neuroscience2022

Early life stress is associated with the default mode and fronto-limbic network connectivity among young adults.

Miro Ilomäki, Jallu Lindblom, Viljami Salmela, Marjo Flykt, Mervi Vänskä, Juha Salmi, Tuija Tolonen, Kimmo Alho, Raija-Leena Punamäki, Patrik Wikman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  7. The Effects of Adverse Life Events on Brain Development in the ABCD StudymedRxiv : the preprint server for health sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Miro IlomäkiDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Jallu LindblomFaculty of Social Sciences/Psychology, Tampere University, Tampere, Finland.
Viljami SalmelaDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Marjo FlyktDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Mervi VänskäFaculty of Social Sciences/Psychology, Tampere University, Tampere, Finland.
Juha SalmiDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Tuija TolonenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Kimmo AlhoDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Raija-Leena PunamäkiFaculty of Social Sciences/Psychology, Tampere University, Tampere, Finland.
Patrik WikmanDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Tampere University · FIUniversity of Helsinki · FIAalto University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to early life stress (ELS) is associated with a variety of detrimental psychological and neurodevelopmental effects. Importantly, ELS has been associated with regional alterations and aberrant connectivity in the structure and functioning of brain regions involved in emotion processing and self-regulation, creating vulnerability to mental health problems. However, longitudinal research regarding the impact of ELS on functional connectivity between brain regions in the default mode network (DMN) and fronto-limbic network (FLN), both implicated in emotion-related processes, is relatively scarce. Neuroimaging research on ELS has mostly focused on single nodes or bi-nodal connectivity instead of functional networks. We examined how ELS is associated with connectivity patterns within the DMN and FLN during rest in early adulthood. The participants (

Indexed as

adverse childhood experience (ACE)default mode network (DMN)early life stress (ELS)fronto-limbic networkfunctional connectivity

Identifiers

PMID36212193
PMCPMC9537946
OpenAlexW4296997445

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.