Evidence map›Paper›PMID 36212140›Full record

ReviewFrontiers in genetics2022

Epigenetic factors in breast cancer therapy.

Runjhun Mathur, Niraj Kumar Jha, Gaurav Saini, Saurabh Kumar Jha, Sheo Prasad Shukla, Zita Filipejová, Kavindra Kumar Kesari, Danish Iqbal, Parma Nand, Vijay Jagdish Upadhye and 3 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Runjhun MathurDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India.
Niraj Kumar JhaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India.
Gaurav SainiDepartment of Civil Engineering, Netaji Subhas University of Technology, Delhi, India.
Saurabh Kumar JhaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India.
Sheo Prasad ShuklaDepartment of Civil Engineering, Rajkiya Engineering College, Banda, India.
Zita FilipejováSmall Animal Clinic, University of Veterinary Sciences Brno, Brno, Czechia.
Kavindra Kumar KesariDepartment of Applied Physics, School of Science, Aalto University, Espoo, Finland.
Danish IqbalDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majma'ah, Saudi Arabia.
Parma NandDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India.
Vijay Jagdish UpadhyeCenter of Research for Development (CR4D), Parul Institute of Applied Sciences (PIAS), Parul University, Vadodara, Gujarat.
Abhimanyu Kumar JhaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India.
Shubhadeep RoychoudhuryDepartment of Life Science and Bioinformatics, Assam University, Silchar, India.
Petr SlamaDepartment of Animal Morphology, Physiology, and Genetics, Faculty of AgriSciences, Mendel University in Brno, Brno, Czechia.
Sharda University · INAalto University · FIAssam University · INChandigarh University · INMajmaah University · SAMendel University in Brno · CZNetaji Subhas University of Technology · INParul University · INUniversity of Veterinary Sciences Brno · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic modifications are inherited differences in cellular phenotypes, such as cell gene expression alterations, that occur during somatic cell divisions (also, in rare circumstances, in germ line transmission), but no alterations to the DNA sequence are involved. Histone alterations, polycomb/trithorax associated proteins, short non-coding or short RNAs, long non-coding RNAs (lncRNAs), & DNA methylation are just a few biological processes involved in epigenetic events. These various modifications are intricately linked. The transcriptional potential of genes is closely conditioned by epigenetic control, which is crucial in normal growth and development. Epigenetic mechanisms transmit genomic adaptation to an environment, resulting in a specific phenotype. The purpose of this systematic review is to glance at the roles of Estrogen signalling, polycomb/trithorax associated proteins, DNA methylation in breast cancer progression, as well as epigenetic mechanisms in breast cancer therapy, with an emphasis on functionality, regulatory factors, therapeutic value, and future challenges.

Indexed as

breastcancerepigeneticsestrogentherapy

Identifiers

PMID36212140
PMCPMC9539821
OpenAlexW4296995391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.