Evidence map›Paper›PMID 36212078›Full record

ArticleMaterials today. Advances2022

Silk fibers assisted long-term 3D culture of human primary urinary stem cells via inhibition of senescence-associated genes: Potential use in the assessment of chronic mitochondrial toxicity.

Huifen Ding, Sunil George, Xiaoyan Iris Leng, Michael Ihnat, Jian-Xing Ma, Guochun Jiang, David Margolis, Julie Dumond, Yuanyuan Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Huifen DingWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Sunil GeorgeWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Xiaoyan Iris LengDivision of Public Health Sciences, Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Michael IhnatDepartment of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Jian-Xing MaDepartment of Biochemistry, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Guochun JiangUniversity of North Carolina HIV Cure Center, UNC Chapel Hill, Chapel Hill, NC, USA.
David MargolisUniversity of North Carolina HIV Cure Center, UNC Chapel Hill, Chapel Hill, NC, USA.
Julie DumondDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, UNC Chapel Hill, Chapel Hill, NC, USA.
Yuanyuan ZhangWake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Wake Forest University · USUniversity of North Carolina at Chapel Hill · USForest Institute · USStomatological Hospital of Chongqing Medical University · CNUniversity of North Carolina Health Care · USUniversity of Oklahoma Health Sciences Center · US

Funding

3D Culture Systems Of Urine-Derived Stem Cell For NTRI-Induced Mitotoxicity AssessmentR21AI152832 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2020 to 2021
$426k
Silk Fibers-Assisted 3D System for Large-Scale Culture of Human Urine-Derived Stem Cells Suitable for Late Mitotoxicity TestingR03AI165170 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZHANG, YUANYUAN NO · 2021 to 2022
$155k
NIAID NIH HHS R03 AI165170NIAID NIH HHS R21 AI152832
6 · The paper itself

Abstract

Despite being widely applied in drug development, existing

Indexed as

3D cellular assayAntiviral drugsHuman stem cellsMitochondrial toxicitySilk fibersSpheroids

Identifiers

PMID36212078
PMCPMC9542430
OpenAlexW4282835789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.