Evidence map›Paper›PMID 36211978›Full record

ReviewFrontiers in molecular neuroscience2022

Attention-deficit/hyperactive disorder updates.

Miriam Kessi, Haolin Duan, Juan Xiong, Baiyu Chen, Fang He, Lifen Yang, Yanli Ma, Olumuyiwa A Bamgbade, Jing Peng, Fei Yin

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 65 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Serotonin dysfunction in ADHD.Journal of neurodevelopmental disorders · 2025
    Review
  11. [Early lifeNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Efficacy and safety of guanfacine in hospitalized patients with delirium: A scoping review.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Miriam KessiDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Haolin DuanDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Juan XiongDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Baiyu ChenDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Fang HeDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Lifen YangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Yanli MaDepartment of Neurology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China.
Olumuyiwa A BamgbadeDepartment of Anesthesiology and Pharmacology, University of British Columbia, Vancouver, BC, Canada.
Jing PengDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Fei YinDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CNUniversity of British Columbia · CAZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Attention-deficit/hyperactive disorder (ADHD) is a neurodevelopmental disorder that commonly occurs in children with a prevalence ranging from 3.4 to 7.2%. It profoundly affects academic achievement, well-being, and social interactions. As a result, this disorder is of high cost to both individuals and society. Despite the availability of knowledge regarding the mechanisms of ADHD, the pathogenesis is not clear, hence, the existence of many challenges especially in making correct early diagnosis and provision of accurate management. Objectives: We aimed to review the pathogenic pathways of ADHD in children. The major focus was to provide an update on the reported etiologies in humans, animal models, modulators, therapies, mechanisms, epigenetic changes, and the interaction between genetic and environmental factors. Methods: References for this review were identified through a systematic search in PubMed by using special keywords for all years until January 2022. Results: Several genes have been reported to associate with ADHD: Conclusion: The dopaminergic pathway remains to be crucial in the pathogenesis of ADHD. It can be affected by environmental factors and other pathways. Nevertheless, it is still unclear how environmental factors relate to all neurotransmitter pathways; thus, more studies are needed. Although several genes have been related to ADHD, there are few animal model studies on the majority of the genes, and they do not generate the genetic alteration of the patients. More animal models and epigenetic studies are required.

Indexed as

attention-deficit/hyperactive disordercopy number variationsenvironmental factorsgenesmicroRNAs (miRNAs)pathogenic pathways

Identifiers

PMID36211978
PMCPMC9532551
OpenAlexW4296736954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.