Evidence map›Paper›PMID 36211969›Full record

ArticleFrontiers in cellular and infection microbiology2022

Meningococcal virulence in zebrafish embryos depends on capsule polysaccharide structure.

Kim Schipper, Lisanne C Preusting, Nina M van Sorge, Yvonne Pannekoek, Arie van der Ende

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kim SchipperAmsterdam University Medical Centers, Location University of Amsterdam, Amsterdam Infection Immunity, Department of Medical Microbiology and Infection Prevention Netherlands Reference Laboratory for Bacterial Meningitis, Location AMC, Amsterdam, Netherlands.
Lisanne C PreustingAmsterdam University Medical Centers, Location University of Amsterdam, Amsterdam Infection Immunity, Department of Medical Microbiology and Infection Prevention Netherlands Reference Laboratory for Bacterial Meningitis, Location AMC, Amsterdam, Netherlands.
Nina M van SorgeAmsterdam University Medical Centers, Location University of Amsterdam, Amsterdam Infection Immunity, Department of Medical Microbiology and Infection Prevention Netherlands Reference Laboratory for Bacterial Meningitis, Location AMC, Amsterdam, Netherlands.
Yvonne PannekoekAmsterdam University Medical Centers, Location University of Amsterdam, Amsterdam Infection Immunity, Department of Medical Microbiology and Infection Prevention Netherlands Reference Laboratory for Bacterial Meningitis, Location AMC, Amsterdam, Netherlands.
Arie van der EndeAmsterdam University Medical Centers, Location University of Amsterdam, Amsterdam Infection Immunity, Department of Medical Microbiology and Infection Prevention Netherlands Reference Laboratory for Bacterial Meningitis, Location AMC, Amsterdam, Netherlands.
University of Amsterdam · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conclusion: Meningococcal virulence in the zebrafish embryo largely depends on the presence of the polysaccharide capsule but the extent of the contribution is determined by its structure. The observed differences between the meningococcal isogenic capsule variants in zebrafish embryo virulence may depend on differences in metabolic cost.

Indexed as

Neisseria meningitidisZebrafishAnimalsBacterial CapsulesMammalsPolysaccharidesVirulenceVirulence FactorsPolysaccharidesVirulence Factorsinnate immunityisogenic capsule variantsmeningococcal polysaccharide capsuleNeisseria meningitidiszebrafish embryo infection

Identifiers

PMID36211969
PMCPMC9538531
OpenAlexW4297009547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.