Evidence map›Paper›PMID 36211962›Full record

ArticleFrontiers in cellular and infection microbiology2022

Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of intracellular iron and reactive oxygen species of macrophages in response to

Chenjie Ma, Xiaoling Wu, Xu Zhang, Xiaoming Liu, Guangcun Deng

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Recent progress in understanding ferroptosis mechanisms in infectious diseases.Frontiers in cellular and infection microbiology · 2026
    Review
  5. The promising arsenal of ferroptosis inducers in bladder cancer.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  6. Inactivation of glutathioneGut microbes · 2025
    Article
  7. Review
  8. Review
  9. Cell death pathways in response toInfection and immunity · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. The interplay of miRNAs and ferroptosis in diseases related to iron overload.Apoptosis : an international journal on programmed cell death · 2024
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Chenjie MaKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University, Yinchuan, China.
Xiaoling WuKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University, Yinchuan, China.
Xu ZhangDepartment of Beijing National Biochip Research Center sub-center in Ningxia, General Hospital of Ningxia Medical University, Yinchuan, China.
Xiaoming LiuKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University, Yinchuan, China.
Guangcun DengKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University, Yinchuan, China.
Ningxia University · CNNingxia Medical University General Hospital · CN

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

Macrophages are the host cells and the frontline defense against

Indexed as

FerroptosisMycobacterium bovisTuberculosisTuberculosis, PulmonaryAnimalsAntioxidantsBCG VaccineCysteineCytokinesHeme Oxygenase-1IronMacrophagesMembrane ProteinsMicePhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesAntioxidantsBCG VaccineCysteineCytokinesHeme Oxygenase-1Hmox1 protein, mouseIronMembrane ProteinsPhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesRNA, Small InterferingBacillus Calmat and GuerinferroptosisHeme oxygenase-1macrophageMycobacterium tuberculosis

Identifiers

PMID36211962
PMCPMC9539760
OpenAlexW4296999505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.