Evidence map›Paper›PMID 36211602›Full record

ArticleFrontiers in allergy2022

miR-155 Is a Positive Regulator of FcεRI-Induced Cyclooxygenase-2 Expression and Cytokine Production in Mast Cells.

Zahraa Mohammed, Cody McHale, Jason L Kubinak, Stuart Dryer, Gregorio Gomez

Open access · goldAbstract read
In one paragraph

Article in Frontiers in allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Zahraa MohammedDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
Cody McHaleMolecular Targeted Therapeutics Laboratory, Levine Cancer Institute, Charlotte, NC, United States.
Jason L KubinakDepartment of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.
Stuart DryerDepartment of Biology and Biochemistry, College of Natural Sciences and Mathematics, University of Houston, Houston, TX, United States.
Gregorio GomezDepartment of Biomedical Sciences, College of Medicine, University of Houston, Houston, TX, United States.
University of Houston · USUniversity of South Carolina · USTarget (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis. A few roles for miR-155 have been described in mast cells and some specifically related to IgE receptor signaling, but it is not completely understood. Here, we demonstrate by miRNA seq profiling and quantitative RT-PCR that miR-155 expression is significantly increased in human skin-derived mast cells (SMCs) and mouse bone marrow-derived mast cells (BMMCs) following FcεRI crosslinking with antigen. We demonstrate that FcεRI-induced expression of

Indexed as

AktallergyCOX-2FcεRImast cellsmiR-155

Identifiers

PMID36211602
PMCPMC9543708
OpenAlexW4224128519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.