ArticleFrontiers in cardiovascular medicine2022
Twenty-four hour variability of inverted T-waves in patients with apical hypertrophic cardiomyopathy.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- ST-Segment Elevation Myocardial Infarction Presentation in Apical Hypertrophic Cardiomyopathy.JACC. Case reports · 2025Article
- Identifying Hypertrophic or Dilated Cardiomyopathy: Development and Validation of a Fine-Tuned ResNet50 Model Based on Electrocardiogram Image.Bioengineering (Basel, Switzerland) · 2025Article
- The identification and prediction of atrial fibrillation in coronary artery disease patients: a multicentre retrospective study based on Bayesian network.Annals of medicine · 2024Article
- Electrophysiological mechanisms underlying T wave pseudonormalisation on stress ECGs in hypertrophic cardiomyopathy.Computers in biology and medicine · 2024Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
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Abstract
Background: Patients with apical hypertrophic cardiomyopathy (ApHCM) have marked inverted T-waves that vary over several years. Inverted T-waves in ApHCM are unstable, but it is unclear whether this change is due to coronary artery disease (CAD) or if it is a characteristic of ApHCM itself. We aimed to study the characteristics of inverted T-waves in patients with ApHCM over the course of 24 h to improve the diagnostic indices of ApHCM. Methods: We examined 83 patients with ApHCM and 89 patients with CAD (who served as the control group). All patients underwent a 24-h dynamic electrocardiogram (ECG). We analyzed the average depth of inverted T-waves per minute and sorted them from shallow to deep; the sorted ECG segments at the 10 Results: The amplitudes of inverted T-waves in ApHCM corresponding to the 10 Conclusion: Notable variations in the T-waves of patients with ApHCM were observed over 24 h. ECG examinations during states of inactivity (comparable to sleep) improved the sensitivity of the diagnosis of ApHCM. Inverted T-wave amplitudes correlated with heart rate and circadian rhythm, where T-wave changes in ApHCM may be due to the normalization of abnormal T-waves effect. Identifying T-wave amplitudes >10 mm can effectively improve the diagnostic rate of ApHCM, especially in patients aged <50 years. The short-term change in T-waves in patients with ApHCM could serve as a novel index that will help in the diagnosis of ApHCM.
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