Evidence map›Paper›PMID 36211450›Full record

ArticleFrontiers in cell and developmental biology2022

Bioinformatic analysis of the

Saverio Candido, Barbara Tomasello, Alessandro Lavoro, Luca Falzone, Giuseppe Gattuso, Angela Russo, Sabrina Paratore, James A McCubrey, Massimo Libra

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Regulation of mitochondrial iron homeostasis in tumor cells.Molecular medicine (Cambridge, Mass.) · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Natural Compounds and Glutathione: Beyond Mere Antioxidants.Antioxidants (Basel, Switzerland) · 2023
    Review
  9. Effects of DNA, RNA, and Protein Methylation on the Regulation of Ferroptosis.International journal of biological sciences · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Saverio CandidoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Barbara TomaselloDepartment of Drug and Health Sciences, University of Catania, Catania, Italy.
Alessandro LavoroDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Luca FalzoneEpidemiology Unit, IRCCS Istituto Nazionale Tumori "Fondazione G. Pascale", Naples, Italy.
Giuseppe GattusoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Angela RussoPathological Anatomy Unit, ARNAS Garibaldi Hospital, Catania, Italy.
Sabrina ParatorePathological Anatomy Unit, ARNAS Garibaldi Hospital, Catania, Italy.
James A McCubreyDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Massimo LibraDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
University of Catania · ITOspedale Garibaldi · ITEast Carolina University · USIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several features of cancer cells such as proliferation, invasion, metastatic spreading, and drug resistance are affected by their interaction with several tumor microenvironment (TME) components, including neutrophil gelatinase-associated lipocalin (NGAL), solute carrier family 22 member 17 (SLC22A17), and matrix metallopeptidase 9 (MMP9). These molecules play a key role in tumor growth, invasion, and iron-dependent metabolism of cancer cells. However, the precise epigenetic mechanisms underlying the gene regulation of

Indexed as

bioinformaticcancerDNA methylationferroptosisgene expressionLCN2MMP9SLC22A17

Identifiers

PMID36211450
PMCPMC9532607
OpenAlexW4296733829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.