ReviewFrontiers in immunology2022
Update on mosquito bite reaction: Itch and hypersensitivity, pathophysiology, prevention, and treatment.
Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Prevalence and risk factors of papular urticaria among school children in Cartagena, Colombia.The World Allergy Organization journal · 2026Article
- Mouse chymase mast cell protease-4 facilitates blood feeding of Aedes aegypti (Diptera: Culicidae) mosquitoes.Journal of medical entomology · 2026Article
- Contribution of Immune Responses toJournal of inflammation research · 2026Article
- Seasonal dynamics and species diversity of Anopheles mosquitoes in malaria endemic districts of Southern Odisha India.Scientific reports · 2025Article
- Allergic reactions associated with tsetse fly bites.Annals of medicine · 2025Article
- Indigenous knowledge and plant species used as mosquito repellents in the West Nile Subregion, Uganda.Tropical medicine and health · 2025Article
- A capture enzyme-linked immunosorbent assay for detection of mosquito salivary protein-specific immunoglobulin E.PLoS neglected tropical diseases · 2025Article
- Evaluating the Metrics of Insecticide Resistance and Efficacy: Comparison of the CDC Bottle Bioassay with Formulated and Technical-Grade Insecticide and a Sentinel Cage Field Trial.Tropical medicine and infectious disease · 2025Article
- Evaluation ofThe World Allergy Organization journal · 2025Article
- Ultrasound evaluation of superficial lesions caused by ectoparasites in children.Pediatric radiology · 2025Review
- Practical guide for the diagnosis and treatment of localized and generalized cutaneous pruritus (chronic itch with no underlying pruritic dermatosis).The Journal of dermatology · 2025Review
- Genetic and Immunological Insights into Tick-Bite Hypersensitivity and Alpha-Gal Syndrome: A Case Study Approach.International journal of molecular sciences · 2025Article
- Unraveling the Molecular Mechanisms of Mosquito Salivary Proteins: New Frontiers in Disease Transmission and Control.Biomolecules · 2025Review
- A rare allergic disease due to mosquito bite: Skeeter syndrome.Postepy dermatologii i alergologii · 2025Article
- Use of over-the-counter antiallergic products-analysis of sales data in Poland from 2020 to 2023.Frontiers in pharmacology · 2025Article
- Effectiveness of the antihistamine and anti-PAF effects of rupatadine in allergic diseases: off-label use in a case series study.Drugs in context · 2025Article
- Insect-specific virus platforms for arbovirus vaccine development.Frontiers in immunology · 2025Review
- RepeatedFrontiers in microbiology · 2025Article
- Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis.CNS neuroscience & therapeutics · 2024Article
- How using light touch immersion research revealed important insights into the lack of progress in malaria elimination in Eastern Indonesia.Malaria journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mosquito bites are endured by most populations worldwide. Reactions to mosquito bites range from localized wheals and papules with associated pruritus to rare systemic reactions and anaphylaxis in certain populations. The mechanism of itch is due to introduction of mosquito saliva components into the cutaneous tissue, although the exact pathophysiology is unclear. Histamine is thought to be a key player through mosquito saliva itself or through activation of mast cells by IgE or through an IgE-independent pathway. However, other salivary proteins such as tryptase and leukotrienes may induce non-histaminergic itch. Some individuals have a genetic predisposition for mosquito bites, and people with hematologic cancers, HIV, and other conditions are susceptible to robust reactions. Prevention of mosquito bites is key with physical barriers or chemical repellents. Treatment consists of second-generation antihistamines and topical corticosteroids. Further research on topical treatments that target neural-mediated itch is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.