ArticleFrontiers in immunology2022
Maternal gut microbiota during pregnancy and the composition of immune cells in infancy.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- Fermented Foods, Functional Nutrition, and Maternal Gut Microbiota During Pregnancy: Molecular Mechanisms and the Maternal-Infant Microbiome Axis.International journal of molecular sciences · 2026Review
- Early-life microbiota exposure and prevention of childhood asthma: immunological mechanisms and intervention perspectives.Frontiers in pediatrics · 2026Review
- The maternal gut-fetal brain axis: role of maternal microbial metabolome in early neurodevelopment.Frontiers in nutrition · 2026Review
- Current Research in Fermented Foods: Bridging Tradition and Science.Advances in nutrition (Bethesda, Md.) · 2025Review
- Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?Antioxidants (Basel, Switzerland) · 2025Review
- Gut Microbiome Dysbiosis and Its Impact on Reproductive Health: Mechanisms and Clinical Applications.Metabolites · 2025Review
- The Effects of Fecal Microbial Transplantation on the Symptoms in Autism Spectrum Disorder, Gut Microbiota and Metabolites: A Scoping Review.Microorganisms · 2025Review
- Interactions of the maternal microbiome with diet, stress, and infection influence fetal development.The FEBS journal · 2025Review
- Higher gut Bacteroidetes and Actinobacteria population in early pregnancy is associated with lower risk of gestational diabetes in the second trimester.BMC pregnancy and childbirth · 2025Article
- Unraveling the role of the gut microbiome in pregnancy disorders: insights and implications.Frontiers in cellular and infection microbiology · 2025Review
- Association Between Maternal IBD-Related Antibodies and Early Life Gut Inflammatory Status and Microbiota Composition: Insights from Cord Blood.Journal of inflammation research · 2025Article
- A maternal sweet diet is associated with the gut dysbiosis in the first trimester of pregnancy.BMC nutrition · 2024Article
- Article
- Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review).Oncology letters · 2024Review
- The maternal gut microbiome in pregnancy: implications for the developing immune system.Nature reviews. Gastroenterology & hepatology · 2024Review
- Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology.Frontiers in immunology · 2024Review
- Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Preclinical studies have shown that maternal gut microbiota during pregnancy play a key role in prenatal immune development but the relevance of these findings to humans is unknown. The aim of this prebirth cohort study was to investigate the association between the maternal gut microbiota in pregnancy and the composition of the infant's cord and peripheral blood immune cells over the first year of life. Methods: The Barwon Infant Study cohort ( Results: We identified six clusters of co-occurring OTUs. The first two components in the PLS regression explained 39% and 33% of the covariance between the maternal prenatal OTU clusters and immune cell populations in offspring at birth. A cluster in which Conclusion: This birth cohort study provides evidence consistent with past preclinical models that the maternal gut microbiota during pregnancy plays a role in shaping the composition of innate and adaptive elements of the infant's immune system following birth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.