Evidence map›Paper›PMID 36211411›Full record

Trial reportFrontiers in immunology2022

Evidence of maternal transfer of antigen-specific antibodies in serum and breast milk to infants at high-risk of

Kelly M Martinovich, Elke J Seppanen, Amy S Bleakley, Sharon L Clark, Ross M Andrews, Peter C Richmond, Michael J Binks, Ruth B Thornton, Lea-Ann S Kirkham

2 registry-linked trialsOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00310349 phase3unknown statusnot on this map

PneuMum: A Randomised Controlled Trial of Pneumococcal Polysaccharide Vaccination for Aboriginal and Torres Strait Islander Mothers to Protect Their Babies From Ear Disease

TypeinterventionalSponsorUniversity of MelbourneRan2006 to 2009Enrolled210ConditionsMiddle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal InfectionsArms23 valent pneumococcal polysaccharide vaccine
NCT00714064 phase3completednot on this map

PneuMum: A Randomised Controlled Trial of Pneumococcal Polysaccharide Vaccination for Aboriginal and Torres Strait Islander Mothers to Protect Their Babies From Ear Disease

TypeinterventionalSponsorMenzies School of Health ResearchRan2006 to 2011Enrolled227ConditionsMiddle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal InfectionsArms23vPPV, dTpa (Pneumovax, Boostrix)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kelly M MartinovichWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
Elke J SeppanenWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
Amy S BleakleyMenzies School of Health Research Charles, Darwin University, Darwin, NT, Australia.
Sharon L ClarkWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
Ross M AndrewsResearch School of Population Health, Australian National University, Canberra, ACT, Australia.
Peter C RichmondWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
Michael J BinksMenzies School of Health Research Charles, Darwin University, Darwin, NT, Australia.
Ruth B ThorntonWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
Lea-Ann S KirkhamWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
The Kids Research Institute Australia · AUUniversity of Western Australia · AUCharles Darwin University · AUAustralian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Children in low-mid income countries, and First Nations children in high-income countries, experience disproportionately high rates of Methods: Breast milk, infant nasopharyngeal swabs and ear assessment data were collected 1-, 2-, 7-months post-birth as well as maternal, cord and 7-month-old infant sera, from 85 Australian Aboriginal and Torres Strait Islander mother-infant pairs. Serum IgG and breast milk IgG and IgA antibody titres to Results: IgG titres in maternal and cord sera were similar for all antigens, except Ply (higher in cord; p=0.004). Sera IgG titres at 7-months of age were lower than cord sera IgG titres for all Conclusions: Similarities between maternal and cord IgG titres, and absence of waning, support a lack of maternal Trial registration: ClinicalTrials.gov NCT00714064 and NCT00310349.

Indexed as

Otitis MediaPneumoniaAntibodies, BacterialAntigens, BacterialAustraliaFemaleHaemophilus influenzaeHumansImmunoglobulin AImmunoglobulin GInfantMilk, HumanPlacentaPregnancyStreptococcus pneumoniaeAntibodies, BacterialAntigens, BacterialImmunoglobulin AImmunoglobulin Gbreast milkHaemophilus influenzaeIgAIgGmaternalStreptococcus pneumoniae

Identifiers

PMID36211411
PMCPMC9535341
OpenAlexW4296633054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.