Evidence map›Paper›PMID 36211390›Full record

ArticleFrontiers in immunology2022

Unique profile of predominant CCR5-tropic in CRF07_BC HIV-1 infections and discovery of an unusual CXCR4-tropic strain.

Xiaoyan Hu, Yi Feng, Kang Li, Yueyang Yu, Abdur Rashid, Hui Xing, Yuhua Ruan, Lingling Lu, Min Wei, Yiming Shao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Xiaoyan HuSchool of Medicine, Nankai University, Tianjin, China.
Yi FengState Key Laboratory for Infectious Disease Prevention and Control, National Center for Acquired Immune Deficiency Syndrome/Sexually Transmitted Diseases (AIDS/STD) Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Kang LiCollege of Life Sciences, Nankai University, Tianjin, China.
Yueyang YuSchool of Medicine, Nankai University, Tianjin, China.
Abdur RashidSchool of Medicine, Nankai University, Tianjin, China.
Hui XingState Key Laboratory for Infectious Disease Prevention and Control, National Center for Acquired Immune Deficiency Syndrome/Sexually Transmitted Diseases (AIDS/STD) Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Yuhua RuanState Key Laboratory for Infectious Disease Prevention and Control, National Center for Acquired Immune Deficiency Syndrome/Sexually Transmitted Diseases (AIDS/STD) Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Lingling LuSchool of Medicine, Nankai University, Tianjin, China.
Min WeiSchool of Medicine, Nankai University, Tianjin, China.
Yiming ShaoSchool of Medicine, Nankai University, Tianjin, China.
Nankai University · CNChinese Center For Disease Control and Prevention · CNNational Center for AIDS/STD Control and Prevention,China CDC · CNNational Institute for Communicable Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRF07_BC is one of the most prevalent HIV-1 strains in China, which contributes over one-third of the virus transmissions in the country. In general, CRF07_BC is associated with slower disease progression, while the underlying mechanisms remain unclear. Our study focused on envelope proteins (Env) and its V3 loop which determine viral binding to co-receptors during infection of cells. We studied a large dataset of 3,937

Indexed as

HIV-1HIV InfectionsChinaGene Products, envHumansReceptors, CCR5Receptors, CXCR4Virus AttachmentCCR5 protein, humanCXCR4 protein, humanGene Products, envReceptors, CCR5Receptors, CXCR4CCR5CRF07_BCCXCR4HIV-1tropism

Identifiers

PMID36211390
PMCPMC9540210
OpenAlexW4297011925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.