ArticleClinical psychological science : a journal of the Association for Psychological Science2022
Gray-Matter Morphometry of Internalizing-Symptom Dimensions During Adolescence.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Associations between early life adversity and the development of gray matter macrostructure and microstructure.Psychological medicine · 2025Article
- Intrinsic Functional Connectivity Associated with γ‑Aminobutyric Acid and Glutamate/Glutamine in the Lateral Prefrontal Cortex and Internalizing Psychopathology in Adolescents.Neuroscience bulletin · 2025Article
- Evidence of Disrupted Hippocampal Gray- and White-Matter Development in Adolescent Anxiety Disorders, Independent From Early-Life Stress.Hippocampus · 2025Article
- Prospective Relations between Cortical Thickness and Change in Internalizing Symptoms are Moderated by Chronic Stress Exposure in Adolescents with Depression and Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Individual differences in intolerance of uncertainty is primarily linked to the structure of inferior frontal regions.Cognitive, affective & behavioral neuroscience · 2025Article
- Parent Psychopathology and Behavioral Effects on Child Brain-Symptom Networks in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
- Combining dimensional models of internalizing symptoms and repetitive negative thought: Systematic replication, model comparison, and external validation.Journal of psychopathology and clinical science · 2023Article
- Sex and age variations in the impact of puberty on cortical thickness and associations with internalizing symptoms and suicidal ideation in early adolescence.Developmental cognitive neuroscience · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Understanding the neuroanatomical correlates of internalizing psychopathology during adolescence may shed light on to neurodevelopmental processes that make this a critical period for the trajectory of mental illness. However, few studies have simultaneously examined co-occurring and dissociable features of internalizing psychopathology during this formative developmental stage. In the current study we identify the neuroanatomical correlates of four dimensions of internalizing psychopathology symptoms in adolescents: a common internalizing dimension capturing covariance in symptoms across internalizing disorders, as well as low positive affect-, anxious arousal-, and anxious apprehension-specific residuals. Our results suggest that these dimensions are associated with neuroanatomy across much of the brain, including prefrontal and limbic regions implicated in case-control studies, but also regions supporting visual processing. Importantly, results differed between males and females in regions that are sexually dimorphic in adulthood and the direction of the effects were largely opposite to what has been observed in adults and children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.