Evidence map›Paper›PMID 36211116›Full record

ArticleCureus2022

A Case Report of Nodular Regenerative Hyperplasia and Non-cirrhotic Portal Hypertension Post Oxaliplatin Chemotherapy.

Nagapratap Ganta, Ankita Prasad, Mina Aknouk, Kajal Ghodasara, Ambica Nair, Zehra Taqvi, Pramil Cheriyath

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nagapratap GantaInternal Medicine, Hackensack Meridian Health Ocean University Medical Center, Brick, USA.
Ankita PrasadInternal Medicine, Hackensack Meridian Health Ocean University Medical Center, Brick, USA.
Mina AknoukInternal Medicine, Hackensack Meridian Health Ocean University Medical Center, Brick, USA.
Kajal GhodasaraInternal Medicine, Hackensack Meridian Health Ocean University Medical Center, Brick, USA.
Ambica NairInternal Medicine, Hackensack Meridian Health Ocean University Medical Center, Brick, USA.
Zehra TaqviResearch, Hackensack Meridian Health Ocean University Medical Center, Brick, USA.
Pramil CheriyathInternal Medicine, Hackensack Meridian Health Ocean University Medical Center, Brick, USA.
Hackensack Meridian Health · USUniversity Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxaliplatin is widely used in chemotherapeutic regimens for colorectal carcinoma, its recurrence, and metastasis, and is associated with better outcomes. However, oxaliplatin use is associated with injury to hepatic sinusoidal endothelium and the development of nodular regenerative hyperplasia (NRH) in the liver, which can be differentiated from nodular hyperplasia of cirrhosis by the presence of diffuse micronodular transformation without a fibrous band and the lack of perinuclear collagen tissue. This causes non-cirrhotic portal hypertension (NCPH), which presents with splenomegaly and variceal bleeding and preserved synthetic liver function. Its treatment revolves around managing variceal bleeding with banding, sclerotherapy, and beta blockers. Some patients may end up requiring liver transplantation because of recurrent variceal bleeding. We present the case of a 46 years old female who presented with recurrent variceal bleeding due to NCPH and NRH six years after treatment of colon carcinoma with oxaliplatin.

Indexed as

bandingcolon carcinomalynch syndromenodular regenerative hyperplasianon cirrhotic portal hypertensionoxalipatinsclerotherapyvariceal bandingvariceal bleeding

Identifiers

PMID36211116
PMCPMC9528971
OpenAlexW4294433586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.