Evidence map›Paper›PMID 36211025›Full record

ReviewInternational journal of nanomedicine2022

Nanomaterial-Based Drug Delivery Systems: A New Weapon for Cancer Immunotherapy.

Zhengting Jiang, Wenjie Zhang, Jie Zhang, Tian Liu, Juan Xing, Huan Zhang, Dong Tang

Open access · goldAbstract readReview
In one paragraph

Review in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  8. Intratumoral microbiota: a new force in the development and treatment of esophageal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhengting Jiang *Clinical Medical College, Yangzhou University, Yangzhou, 225000, People's Republic of China.
Wenjie Zhang *Clinical Medical College, Yangzhou University, Yangzhou, 225000, People's Republic of China.
Jie ZhangClinical Medical College, Yangzhou University, Yangzhou, 225000, People's Republic of China.
Tian LiuClinical Medical College, Yangzhou University, Yangzhou, 225000, People's Republic of China.ORCID 0000-0002-7113-6015
Juan XingClinical Medical College, Yangzhou University, Yangzhou, 225000, People's Republic of China.
Huan ZhangClinical Medical College, Yangzhou University, Yangzhou, 225000, People's Republic of China.
Dong TangDepartment of General Surgery, Institute of General Surgery, Northern Jiangsu Province Hospital, Clinical Medical College, Yangzhou University, Yangzhou, 225000, People's Republic of China.
Yangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer immunotherapy, a major breakthrough in cancer treatment, has been successfully applied to treat a number of tumors. However, given the presence of factors in the tumor microenvironment (TME) that impede immunotherapy, only a small proportion of patients achieve a good clinical response. With the ability to increase permeability and cross biological barriers, nanomaterials have been successfully applied to deliver immunotherapeutic agents, thus realizing the anti-cancer therapeutic potential of therapeutic agents. This has driven a wave of research into systems for the delivery of immunotherapeutic agents, which has resulted in widespread interest in nanomaterial-based drug delivery systems. Nanomaterial-based drug delivery systems are able to overcome the challenges from TME and thus achieve good results in cancer immunotherapy. If it can make a breakthrough in improving biocompatibility and reducing cytotoxicity, it will be more widely used in clinical practice. Different types of nanomaterials may also have some subtle differences in enhancing cancer immunotherapy. Moreover, delivery systems made of nanomaterials loaded with drugs, such as cytotoxic drugs, cytokines, and adjuvants, could be used for cancer immunotherapy because they avoid the toxicity and side effects associated with these drugs, thereby enabling their reuse. Therefore, further insights into nanomaterial-based drug delivery systems will provide more effective treatment options for cancer patients.

Indexed as

NanostructuresNeoplasmsCytokinesDrug Delivery SystemsHumansImmunologic FactorsImmunotherapyTumor MicroenvironmentCytokinesImmunologic Factorsdelivery systemdrug repurposingimmunotherapynanomaterialtumor microenvironment

Identifiers

PMID36211025
PMCPMC9541303
OpenAlexW4300961775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.