Evidence map›Paper›PMID 36210772›Full record

ArticleACS biomaterials science & engineering2022

Enteric Polymer-Coated Porous Silicon Nanoparticles for Site-Specific Oral Delivery of IgA Antibody.

Tushar Kumeria, Joanna Wang, Byungji Kim, Ji-Ho Park, Jonathan M Zuidema, Mark Klempner, Lisa Cavacini, Yang Wang, Michael J Sailor

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Porous silicon and silica carriers for delivery of peptide therapeutics.Drug delivery and translational research · 2024
    Review
  5. Review
  6. Article
  7. NonviralACS nano · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Tushar KumeriaDepartment of Chemistry and Biochemistry, University of California, San Diego, California 92093, United States.ORCID 0000-0003-3351-7148
Joanna WangMaterials Science and Engineering Program, University of California, San Diego, California 92093, United States.
Byungji KimMaterials Science and Engineering Program, University of California, San Diego, California 92093, United States.
Ji-Ho ParkDepartment of Bio and Brain Engineering, KAIST, Daejeon 34141, Korea.ORCID 0000-0002-0721-0428
Jonathan M ZuidemaDepartment of Chemistry and Biochemistry, University of California, San Diego, California 92093, United States.ORCID 0000-0003-2258-0045
Mark KlempnerMassBiologics of the University of Massachusetts Medical School, Boston, Massachusetts 02126, United States.
Lisa CavaciniMassBiologics of the University of Massachusetts Medical School, Boston, Massachusetts 02126, United States.
Yang WangMassBiologics of the University of Massachusetts Medical School, Boston, Massachusetts 02126, United States.
Michael J SailorDepartment of Chemistry and Biochemistry, University of California, San Diego, California 92093, United States.ORCID 0000-0002-4809-9826
University of California San Diego · USUniversity of Massachusetts Chan Medical School · USKorea Advanced Institute of Science and Technology · KRUNSW Sydney · AU

Funding

Macrophage-targeting Nanoplatforms as Immunotherapy against Pulmonary InfectionsR01AI132413 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael J Sailor · 2017 to 2026
$6.0M
Cancer Researchers in Nanotechnology (CRIN)T32CA153915 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMMEL, ANDREW CLYDE, ZHANG, DONG-ER · 2017 to 2021
$994k
NCI NIH HHS T32 CA153915NIAID NIH HHS R01 AI132413
6 · The paper itself

Abstract

Porous silicon (pSi) nanoparticles are loaded with Immunoglobulin A-2 (IgA2) antibodies, and the assembly is coated with pH-responsive polymers on the basis of the Eudragit family of enteric polymers (L100, S100, and L30-D55). The temporal release of the protein from the nanocomposite formulations is quantified following an

Indexed as

NanoparticlesPolymersGelatinHydrogen-Ion ConcentrationImmunoglobulin AIntestine, SmallPhosphatesPorositySiliconSolubilityGelatinImmunoglobulin APhosphatesPolymersSiliconbiologic antibacterial therapeutics, Eudragit polymeroral drug deliverypH-responsive drug delivery

Identifiers

PMID36210772
PMCPMC10036216
OpenAlexW3107461552

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.