Evidence map›Paper›PMID 36210711›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis].

H Kang, S Jiang, Q Song, Y Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

H KangSchool of Public Health, North China University of Science and Technology, Tangshan 063210, China.
S JiangSchool of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Q SongSchool of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Y ZhangHealth Management Center, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua 325000, China.
North China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the protective effect of cannabinoid receptor 2 (CB2) activation against acute lung injury in rats with lipopolysaccharide (LPS)-induced sepsis and explore the underlying mechanism.

methodsForty-eight SD rats were randomly assigned into control group, model group, CB2 agonist group and P38 MAPK inhibitor group (

resultsThe rat models of sepsis showed severe damage of alveolar structures with significantly decreased fluid clearance rate, lowered pulmonary expressions of CB2, occludin and ZO-1 mRNA and proteins, increased water content in the lung tissue, and increased phosphorylation level of P38 MAPK and TNF-α and IL-1β levels in lung lavage fluid (all

conclusionIn rats with LPS-induced sepsis, activation of CB2 can inhibit the p38 MAPK signaling pathway, reduce the release of inflammatory factors in the lung tissues, promote tight junction protein expressions, and thus offer protection against acute lung injury.

Indexed as

Acute Lung InjurySepsisAnimalsCannabinoidsLipopolysaccharidesLungOccludinp38 Mitogen-Activated Protein KinasesRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB2Receptors, CannabinoidRNA, MessengerTumor Necrosis Factor-alphaWater1,1-dimethylbutyl-1-deoxy-Delta(9)-THCCannabinoidsCnr2 protein, ratLipopolysaccharidesOccludinp38 Mitogen-Activated Protein KinasesReceptor, Cannabinoid, CB2Receptors, CannabinoidRNA, MessengerTumor Necrosis Factor-alphaWatercannabinoid receptor 2P38 lightning MAPKratssepsistight junction protein

Identifiers

PMID36210711
PMCPMC9550549
OpenAlexW4304116477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.