Evidence map›Paper›PMID 36210545›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents.

Haytham O Tawfik, Amany Belal, Mohammed A S Abourehab, Andrea Angeli, Alessandro Bonardi, Claudiu T Supuran, Mervat H El-Hamamsy

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Haytham O TawfikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.ORCID 0000-0001-6455-5716
Amany BelalMedicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.ORCID 0000-0003-1045-0163
Mohammed A S AbourehabDepartment of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.ORCID 0000-0003-1348-6567
Andrea AngeliDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, Italy.ORCID 0000-0002-1470-7192
Alessandro BonardiDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, Italy.
Claudiu T SupuranDepartment of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Sesto Fiorentino, Italy.ORCID 0000-0003-4262-0323
Mervat H El-HamamsyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
University of Florence · ITTanta University · EGAmerican Association of Colleges of Pharmacy · USBeni-Suef University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein we reported the design and synthesis of two series comprising twenty-two benzenesulfonamides that integrate the

Indexed as

Antineoplastic AgentsNeoplasmsBenzenesulfonamidesCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbon IsotopesDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipSulfonamidesTriazinesAntineoplastic AgentsBenzenesulfonamidesCarbon-13Carbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbon IsotopesSulfonamidesTriazinesCA inhibitorscolony formationlinkers flexibilitymolecular dynamicswound healing

Identifiers

PMID36210545
PMCPMC9559471
OpenAlexW4304118660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.