ArticleRespirology (Carlton, Vic.)2023
Causes of hypercapnic respiratory failure and associated in-hospital mortality.
Article in Respirology (Carlton, Vic.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Study of High-Velocity Nasal Insufflation vs Noninvasive Positive Pressure Ventilation for Emergency Type 2 Respiratory Failure: Protocol for a Noninferiority Randomized Controlled Trial.JMIR research protocols · 2026Article
- High-flow nasal cannula versus noninvasive ventilation in stabilized hypercapnic exacerbation: a physiological crossover trial.Annals of intensive care · 2026Article
- Acute hYpErcapnic respiratory failure in The ICU: A multicenter prospective observational study - The YETI study.Annals of intensive care · 2026Article
- The Consistency of Hypercapnic Respiratory Failure Case Definitions in Electronic Health Record Data.Chest · 2026Article
- An Association Between Posterior Reversible Encephalopathy Syndrome and Severe Hypercapnia in Chronic CO₂ Retention.Cureus · 2025Article
- Article
- Prognostic Factors Affecting Mortality Among Patients Admitted to the Intensive Care Unit with Acute Hypoxemic Respiratory Failure.Diagnostics (Basel, Switzerland) · 2025Article
- Predicting Superaverage Length of Stay in COPD Patients with Hypercapnic Respiratory Failure Using Machine Learning.Journal of inflammation research · 2025Article
- Breaking new ground: machine learning enhances survival forecasts in hypercapnic respiratory failure.Frontiers in medicine · 2025Article
- Association of the Neutrophil Percentage-to-Albumin Ratio with All-Cause Mortality in Patients with Hypercapnic Respiratory Failure: A Prospective Cohort Study.International journal of general medicine · 2025Article
- Post-Discharge non-invasive ventilation for hypercapnic respiratory failure: Outcomes in a Rural Cohort.PloS one · 2025Article
- Interleukin 33: a suitable target for biological therapies of COPD?ERJ open research · 2024Article
- Intercostal Muscle Function During Noninvasive Ventilation and Acute Hypercapnic Respiratory Failure.Respiratory care · 2024Article
- The Role of Obstructive Sleep Apnea in Hypercapnic Respiratory Failure Identified in Critical Care, Inpatient, and Outpatient Settings.Sleep medicine clinics · 2024Review
- Increased risk of respiratory events during endobronchial ultrasound examination in patients with reduced forced expiratory volume: a prospective observational study.Frontiers in medicine · 2024Article
- Causes of hypercapnic respiratory failure: a population-based case-control study.BMC pulmonary medicine · 2023Article
- Causes of hypercapnic respiratory failure and associated in-hospital mortality.Respirology (Carlton, Vic.) · 2023Article
- Hypercapnia is associated with an increased risk of ICU admission and reduced inflammatory responses in AECOPD patients with severe pneumonia.Therapeutic advances in respiratory diseaseObservational
- Predictors of invasive mechanical ventilation requirement and mortality in hypercapnic respiratory failure: A retrospective analysis.Turkish journal of emergency medicineArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveHypercapnic respiratory failure (HRF) can occur due to severe respiratory disease but also because of multiple coexistent causes. There are few data on the prevalence of antecedent causes for HRF and the effect of these causes on prognosis, especially where study inclusion has not been biased with respect to primary diagnosis, interventions received or clinical outcome. We sought to determine the prevalence of pre-specified conditions among patients with HRF and to determine the effect of these causes on in-hospital mortality.
methodsCross-sectional study of patients with HRF from 2013 to 2017. Inclusion criteria were PaCO
resultsWe identified 873 persons with HRF in the study period. Mean (SD) age was 69 years and 50.4% were males. Acidosis (pH <7.35) was present in 488 (55%) cases. Most (83%) had one or more of the following: obstructive lung disease, lower respiratory tract infection, congestive cardiac failure, sleep disordered breathing, neuromuscular disease, opioid or benzodiazepine use. In-hospital mortality was 12.8%. Obstructive lung disease and cardiac failure were associated with a lower risk of death, whereas respiratory tract infection and neuromuscular disease were associated with increased risk of death.
conclusionHRF is associated with a range of potentially causative conditions, which significantly impact hospital survival. Systematic evaluation of patients with HRF may increase detection of treatable comorbidities.
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