ArticleMayo Clinic proceedings2022
Peripheral Artery Disease and Subsequent Risk of Infectious Disease in Older Individuals: The ARIC Study.
Article in Mayo Clinic proceedings, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Implementing Oral Antibiotics for Bone and Joint Infections: Lessons Learned and Opportunities for Improvement.Open forum infectious diseases · 2024Trial
- An Unusual Presentation of Salmonella: Cellulitis, Gastroenteritis, and Bacteremia.The American journal of case reports · 2026Article
- Peripheral arterial disease prevalence among sepsis hospitalizations and associated outcomes.Journal of vascular surgery · 2025Article
- Global, regional, and national trends in peripheral arterial disease among older adults: findings from the global burden of disease study 2021.Aging clinical and experimental research · 2025Article
- Subsequent risk of cancer among adults with peripheral artery disease in the community: The atherosclerosis risk in communities (ARIC) study.International journal of cardiology · 2025Article
- Triglyceride-glucose index and the risk of stroke in American adults: findings from the atherosclerosis risk in communities study.Diabetology & metabolic syndrome · 2023Article
- Evaluation of the Risk Factors for Cellulitis among Patients with Peripheral Artery Disease.Medicina (Kaunas, Lithuania) · 2023Article
- Association between multivessel disease and outcomes in acute lower limb ischemia: A cohort study.Science progressObservational
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo quantify the association of peripheral artery disease (PAD) with infection risk because PAD has been understudied despite recognition of atherosclerotic cardiovascular disease as a risk factor for infection.
methodsAmong 5082 participants of the Atherosclerosis Risk in Communities study (aged 71 to 90 years during 2011-2013), we assessed the association of PAD status, based on clinical history and ankle-brachial index (ABI), with infection-related hospitalization (through December 2019) using multivariable Cox regression. We also cross-classified participants by PAD and coronary heart disease (CHD)/stroke status at baseline, with implications for polyvascular disease.
resultsDuring the median follow-up of 6.5 years, there were 1677 infection-related hospitalizations. Peripheral artery disease (clinical history or ABI ≤0.90) was independently associated with the risk of overall infection (adjusted hazard ratio [HR], 1.66 [95% CI, 1.42 to 1.94] vs ABI of 1.11 to 1.20), as was borderline low ABI of 0.91 to 1.00 (adjusted HR, 1.75 [95% CI, 1.47 to 2.07]). Results were consistent across major types of infection (ie, cellulitis, bloodstream infection, pneumonia, and urinary tract infection). For overall infection, PAD plus CHD/stroke had the highest HR of hospitalized infection (1.9), and PAD alone and CHD/stroke alone showed similar HRs of 1.6. For subtypes of infection, PAD alone had the highest HR of approximately 2 for bloodstream infection; PAD alone and PAD plus CHD/stroke had a similar risk of urinary tract infection with HR of approximately 1.7.
conclusionPeripheral artery disease and borderline low ABI were robustly associated with infection-related hospitalization of older adults. The contribution of PAD to infection risk was comparable to that of CHD/stroke, warranting clinical attention to PAD for the prevention of infectious diseases.
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