Evidence map›Paper›PMID 36210051›Full record

ArticleSLAS discovery : advancing life sciences R & D2022

Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein.

Carolina L Haass-Koffler, T Chase Francis, Pauravi Gandhi, Reesha Patel, Mohammad Naemuddin, Carsten K Nielsen, Selena E Bartlett, Antonello Bonci, Stefan Vasile, Becky L Hood and 7 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SLAS discovery : advancing life sciences R & D, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Neuroscience targets and human studies: future translational efforts in the stress system.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Carolina L Haass-KofflerDepartment of Psychiatry and Human Behavior, Alpert Medical School; Department of Behavioral and Social Sciences, School of Public Health; Center for Alcohol and Addiction Studies; Carney Institute for Brain Science, Brown University, Providence RI, United States. Electronic address: carolina_haass-koffler@brown.edu.
T Chase FrancisDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, United States; Intramural Research Program, Integrative Neuroscience Research Branch, National Institute on Drug Abuse Baltimore, MD, United States.
Pauravi GandhiThe Scripps Research Institute, La Jolla, CA, United States.
Reesha PatelThe Scripps Research Institute, La Jolla, CA, United States.
Mohammad NaemuddinDepartment of Neurology, University of California, San Francisco, CA, United States.
Carsten K NielsenDepartment of Neurology, University of California, San Francisco, CA, United States.
Selena E BartlettTranslational Research Institute, School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Queensland, Australia.
Antonello BonciGlobal Institutes on Addictions, Miami FL, United States.
Stefan VasileConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
Becky L HoodConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
Eigo SuyamaConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
Michael P HedrickConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
Layton H SmithConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
Allison S LimpertNCI Designated Cancer Center, La Jolla, CA, United States; Cell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
Marisa RobertoThe Scripps Research Institute, La Jolla, CA, United States.
Nicholas D P CosfordConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States; NCI Designated Cancer Center, La Jolla, CA, United States; Cell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
Douglas J ShefflerNCI Designated Cancer Center, La Jolla, CA, United States; Cell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States. Electronic address: dsheffler@sbpdiscovery.org.
Sanford Burnham Prebys Medical Discovery Institute · USScripps Research Institute · USUniversity of California, San Francisco · USAllen Institute for Brain Science · USGlobal Institutes on Addictions · USNational Institute on Drug Abuse · USTranslational Research Institute · AU

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2M
Sanford-Burnham Center for Chemical GenomicsU54HG005033 · NHGRI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI JACKSON, MICHAEL · 2008 to 2012
$72.5M
Using wearables and EMA to examine the links between cannabis and depressionP20GM130414 · NIGMS · BROWN UNIVERSITY · PI Alexander William Sokolovsky · 2019 to 2026
$22.0M
Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9M
A focus on alpha-1 blockade as a novel pharmacological treatment for alcohol use disorderR01AA027760 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2019 to 2023
$2.6M
Lead optimization of novel CRFBP-CRFR2 complex modulators for alcohol use disorderR01AA026589 · NIAAA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SHEFFLER, DOUGLAS J · 2019 to 2021
$2.4M
Synaptic Mechanisms underlying sex-differences in alcohol use disorderR01AA029841 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2022 to 2026
$2.0M
Identifying Chemical Modulators of CRF-Binding Protein and CRF Receptor ComplexesR33DA029966 · NIDA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI COSFORD, NICHOLAS DAVID · 2012 to 2014
$1.4M
Mifepristone As A Pharmacological Intervention For Stress-Induced Alcohol DrinkingK01AA023867 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2016 to 2020
$901k
Probenecid as pharmacotherapy for alcohol use disorderR21AA027614 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2020 to 2021
$427k
Synaptic and Local Network Mechanisms Underlying Nucleus Accumbens High Frequency StimulationFI2GM128622 · NIGMS · U.S. NATIONAL INSTITUTE ON DRUG ABUSE · PI FRANCIS, TANNER CHASE · 2018 to 2018
–
NCI NIH HHS P30 CA030199NHGRI NIH HHS U54 HG005033NIAAA NIH HHS K01 AA023867NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R01 AA026589NIAAA NIH HHS R01 AA027760NIAAA NIH HHS R01 AA029841NIAAA NIH HHS R21 AA027614NIAAA NIH HHS T32 AA007456NIDA NIH HHS R33 DA029966NIGMS NIH HHS FI2 GM128622NIGMS NIH HHS P20 GM130414NIMH NIH HHS HHSN271201300017CNIMH NIH HHS K99 MH123673
6 · The paper itself

Abstract

backgroundStress responses are believed to involve corticotropin releasing factor (CRF), its two cognate receptors (CRF

methodsWe miniaturized a cell-based assay, where CRFBP(10kD) is fused as a chimera with CRF

resultsWe found that CRFBP(10kD) potentiates CRF-intracellular Ca

conclusionThese results provide the first evidence of specific roles for CRF

Indexed as

Corticotropin-Releasing HormoneResearch DesignAnimalsCarrier ProteinsHEK293 CellsHumansMiceCarrier Proteinscorticotropin releasing factor-binding proteinCorticotropin-Releasing HormoneAUDCRF(2)CRFBPHTSNAMStress

Identifiers

PMID36210051
PMCPMC9762412
OpenAlexW4302774206

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.