ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2022
Outpatient human coronavirus associated conjunctivitis in India.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Use of Large Language Models to Classify Epidemiological Characteristics in Synthetic and Real-World Social Media Posts About Conjunctivitis Outbreaks: Infodemiology Study.Journal of medical Internet research · 2025Article
- Association of Weather Variables With Pathogens Contributing to Conjunctivitis Worldwide.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Etiologies of Infectious Keratitis in Malawi.The American journal of tropical medicine and hygiene · 2024Article
- Use of Large Language Models to Assess the Likelihood of Epidemics From the Content of Tweets: Infodemiology Study.Journal of medical Internet research · 2024Article
- Comprehensive Profile of Pathogens and Antimicrobial Resistance in Conjunctivitis Cases from Niger.The American journal of tropical medicine and hygiene · 2023Article
- Article
- Apollo Rising: Acute Conjunctivitis Outbreak in India, 2022.Cornea open · 2023Article
- Viruses Associated with Acute Conjunctivitis in Vanuatu.The American journal of tropical medicine and hygiene · 2023Article
- Deep sequencing analysis of clinical samples from patients with acute infectious conjunctivitis during the COVID-19 delta surge in Madurai, India.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022Article
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundViral conjunctivitis (pink eye) can be highly contagious and is of public health importance. There remains significant debate whether SARS-CoV-2 can present as a primary conjunctivitis. The aim of this study was to identify pathogens associated with outpatient infectious conjunctivitis during the COVID-19 Delta surge.
methodsThis prospective study was conducted in the spring and summer months of 2021. 106 patients with acute conjunctivitis who presented to the Aravind Eye Center in Madurai, India were included. One anterior nasal swab and one conjunctival swab of each eye were obtained for each enrolled patient. Samples were subsequently processed for unbiased metagenomic RNA deep sequencing (RNA-seq). Outcomes included clinical findings and codetection of other pathogens with SARS-CoV-2 in patients with conjunctivitis.
resultsAmong the 13 patients identified with human coronavirus RNA fragments in their swabs, 6 patients had SARS-CoV-2 infection, 5 patients had coinfections of SARS-CoV-2 and human adenovirus (HAdV), 1 patient had a coinfection with human coronavirus OC43 and HAdV, and 1 patient had a coinfection of Vittaforma corneae and SARS-CoV-2. 30% had bilateral disease and symptoms on presentation. Petechial hemorrhage was noted in 33% of patients with SARS-CoV-2 infection. No patients with SARS-CoV-2 or SARS-CoV-2 and HAdV infections had subepithelial infiltrates on presentation. All patients denied systemic symptoms.
conclusionsAmong the patients presented with conjunctivitis associated with human coronavirus infection, over 50% of the patients had co-infections with other circulating pathogens, suggesting the public-health importance of broad pathogen testing and surveillance in the outpatient conjunctivitis population.
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