SynthesisMaternal and child health journal2022
Periodontitis and Preeclampsia in Pregnancy: A Systematic Review and Meta-Analysis.
Synthesis in Maternal and child health journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Grading the strength and certainty of the scientific evidence of the bidirectional association between periodontitis and noncommunicable diseases: an umbrella review.Evidence-based dentistry · 2025Pooled it
- Interdental Brushing and Obstetrical Outcomes in Nulliparous Pregnant Women: Insights From a Cluster Randomised Controlled Trial.Journal of clinical periodontology · 2026Trial
- Nutrition, Physical Activity and Other Health Aspects Before and During Pregnancy - Recommendations by the Nationwide "Healthy Start Network" (Netzwerk Gesund ins Leben) 2026.Geburtshilfe und Frauenheilkunde · 2026Article
- Preeclampsia, periodontitis and their interactions on cardiometabolic risk markers in pregnancy: A case-control study.Journal of public health research · 2026Article
- Medicaid dental coverage and racial/ethnic variation in preventive dental care and unmet needs during pregnancy.BMC pregnancy and childbirth · 2026Article
- The Oral Microbiome and Systemic Health: Current Insights into the Mouth-Body Connection.Life (Basel, Switzerland) · 2026Review
- Article
- The Role of Medicaid Dental Benefits in Access to Preventive Dental Care and Unmet Dental Needs During Pregnancy.Research square · 2025Article
- Mathematical Modeling of Obstetric Variables: Influence of COVID-19, Periodontal Disease and Dental Care During Pregnancy.Biomedicines · 2025Article
- Dynamic changes in neutrophil activation and metabolic profile during pregnancy are associated with gingival inflammation.Scientific reports · 2025Article
- Review
- Changes, Desire, Fear and Beliefs: Women's Feelings and Perceptions About Dental Care During Pregnancy.International journal of environmental research and public health · 2025Article
- Trophoblast cell response to periodontal pathogens unveils oxidative stress networks between periodontitis and pre-eclampsia: Mendelian randomization, transcriptomic analysis, and cellular experimental validation.European journal of medical research · 2025Article
- A Two-Way Communication Between Apical Periodontitis and Various Systemic Disorders: A Narrative Review.Cureus · 2025Review
- Oral Health Status of Pregnant Women Attending Antenatal Clinic in Cameroon.International journal of MCH and AIDS · 2025Article
- Exploring the Influence of Oral Health on Pregnancy Outcomes: A Narrative Review: Oral Health and Pregnancy Outcomes.Global health, epidemiology and genomics · 2025Review
- Evaluation the Risk of Preeclampsia in Periodontal Patients Compared With Healthy Individuals: A Meta-Analysis Study.International journal of dentistry · 2025Article
- Association of D-dimer, platelet-activating factor, and soluble vascular endothelial growth factor receptor 1 levels with disease severity and prognosis in gestational hypertension.American journal of translational research · 2025Article
- Distinct gut microbial signature and altered short chain fatty acid metabolism at disease onset in a rat preclinical model of superimposed preeclampsia.Scientific reports · 2024Article
- Oral Pathogens' Substantial Burden on Cancer, Cardiovascular Diseases, Alzheimer's, Diabetes, and Other Systemic Diseases: A Public Health Crisis-A Comprehensive Review.Pathogens (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesA conflicting body of evidence suggests localized periodontal inflammation spreads systemically during pregnancy inducing adverse pregnancy outcomes. This systematic review and meta-analysis aim to specifically evaluate the relationship between periodontitis and preeclampsia.
methodsElectronic searches were carried out in Medline, Pubmed, Embase, Lilacs, Cochrane Controlled Clinical Trial Register, CINAHL, ClinicalTrials.gov, and Google Scholar with no restrictions on the year of publication. We identified and selected observational case-control and cohort studies that analyzed the association between periodontal disease and preeclampsia. This meta-analysis was conducted following the PRISMA checklist and MOOSE checklist. Pooled odds ratios, mean difference, and 95% confidence intervals were calculated using the random effect model. Heterogeneity was tested with Cochran's Q statistic.
resultsThirty studies including six cohort- and twenty-four case-control studies were selected. Periodontitis was significantly associated with increased risk for preeclampsia (OR 3.18, 95% CI 2.26 - 4.48, p < 0.00001), especially in a subgroup analysis including cohort studies (OR 4.19, 95% CI 2.23 - 7.87, p < 0.00001). The association was even stronger in a subgroup analysis with lower-middle-income countries (OR 6.70, 95% CI 2.61 - 17.19, p < 0.0001).
conclusionsPeriodontitis appears as a significant risk factor for preeclampsia, which might be even more pronounced in lower-middle-income countries. Future studies to investigate if maternal amelioration of periodontitis prevents preeclampsia might be warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.