Evidence map›Paper›PMID 36209262›Full record

ArticleEJNMMI physics2022

Evaluations of the performances of PET and MRI in a simultaneous PET/MRI instrument for pre-clinical imaging.

Alyssa C Pollard, Jorge de la Cerda, F William Schuler, Charles V Kingsley, Seth T Gammon, Mark D Pagel

Open access · goldAbstract read
In one paragraph

Article in EJNMMI physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alyssa C PollardDepartment of Chemistry, Rice University, Houston, TX, USA.ORCID http://orcid.org/0000-0002-7853-8826
Jorge de la CerdaDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-7344-4249
F William SchulerDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6836-5389
Charles V KingsleyDepartment of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.
Seth T GammonDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8647-0975
Mark D PagelDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA. mdpagel@mdanderson.org.ORCID http://orcid.org/0000-0002-8109-3995
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Measuring Tumor Acidosis with PET/MRI Contrast AgentsR21EB027197 · NIBIB · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAGEL, MARK DAVID · 2019 to 2020
$440k
Measuring tumor acidosis with PET/MRI contrast agentsF31CA247338 · NCI · RICE UNIVERSITY · PI POLLARD, ALYSSA · 2020 to 2021
$92k
NCI NIH HHS F31 CA247338NCI NIH HHS P30 CA016672NIBIB NIH HHS R21 EB027197NIH HHS F31 CA247338NIH HHS P30 CA016672NIH HHS R21 EB027197
6 · The paper itself

Abstract

backgroundPET/MRI is an attractive imaging modality due to the complementary nature of MRI and PET. Obtaining high quality small animal PET/MRI results is key for the translation of novel PET/MRI agents and techniques to the radiology clinic. To obtain high quality imaging results, a hybrid PET/MRI system requires additional considerations beyond the standard issues with separate PET and MRI systems. In particular, researchers must understand how their PET system affects the MR acquisitions and vice versa. Depending on the application, some of these effects may substantially influence image quality. Therefore, the goal of this report is to provide guidance, recommendations, and practical experiments for implementing and using a small animal PET/MRI instrument.

resultsVarious PET and MR image quality parameters were tested with their respective modality alone and in the presence of both systems to determine how the combination of PET/MRI affects image quality. Corrections and calibrations were developed for many of these effects. While not all image characteristics were affected, some characteristics such as PET quantification, PET SNR, PET spatial resolution, PET partial volume effects, and MRI SNR were altered by the presence of both systems.

conclusionsA full exploration of a new PET/MRI system before performing small animal PET/MRI studies is beneficial and necessary to ensure that the new instrument can produce highly accurate and precise PET/MR images.

Indexed as

Fluorine-18Gallium-68Image qualityPET/MRIPositron rangeQuantification

Identifiers

PMID36209262
PMCPMC9547760
OpenAlexW4303671995

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.