ArticleEJNMMI physics2022
Small nuclei identification with a hemispherical brain PET.
Article in EJNMMI physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- PET Imaging of the Human Brain with Microvolumetric Spatial Resolution.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Elevated Thalamic Blood Flow in Self-Limited Epilepsy with Centrotemporal Spikes.bioRxiv : the preprint server for biology · 2025Article
- Visualization of small brain nuclei with a high-spatial resolution, clinically available whole-body PET scanner.Annals of nuclear medicine · 2024Article
- New Horizons in Brain PET Instrumentation.PET clinics · 2024Review
- A conformal TOF-DOI Prism-PET prototype scanner for high-resolution quantitative neuroimaging.Medical physics · 2023Article
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Authors and funding
6 authors.
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Abstract
backgroundTo confirm the performance of the first hemispherical positron emission tomography (PET) for the brain (Vrain) that we developed to visualise the small nuclei in the deep brain area, we compared
methodsTen healthy male volunteers (aged 22-45 years) underwent a representative clinical whole-body PET, followed by Vrain each for 10 min. These two scans were initiated 30 min and 45 min after FDG injection (4.1 ± 0.5 MBq/kg), respectively. First, we visually identified the small nuclei and then compared their standardised uptake values (SUVs) with the participants' age. Next, the SUVs of each brain region, which were determined by applying a volume-of-interest template for anatomically normalised PET images, were compared between the brain images with the Vrain and those with the whole-body PET images.
resultsSmall nuclei, such as the inferior colliculus, red nucleus, and substantia nigra, were more clearly visualised in Vrain than in whole-body PET. The anterior nucleus and dorsomedial nucleus in the thalamus and raphe nucleus in the brainstem were identified in Vrain but not in whole-body PET. The SUVs of the inferior colliculus and dentate gyrus in the cerebellum positively correlated with age (Spearman's correlation coefficient r = 0.811, p = 0.004; r = 0.738, p = 0.015, respectively). The SUVs of Vrain were slightly higher in the mesial temporal and medial parietal lobes than those in whole-body PET.
conclusionsThis was the first time that the raphe nuclei, anterior nuclei, and dorsomedial nuclei were successfully visualised using the first hemispherical brain PET.
trial registrationJapan Registry of Clinical Trials, jRCTs032210086, Registered 13 May 2021, https://jrct.niph.go.jp/latest-detail/jRCTs032210086 .
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