Evidence map›Paper›PMID 36209099›Full record

ReviewImmunity & ageing : I & A2022

Different phenotypes of microglia in animal models of Alzheimer disease.

Yun Wei, Xianxiao Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunity & ageing : I & A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yun WeiXiyuan Hospital of China Academy of Chinese Medical Sciences, 100091, Beijing, China. weiyun_0913@163.com.
Xianxiao LiJingxi Cancer Hospital, 100161, Beijing, China.

Funding

Beijing Natural Science Foundation Project 7222297Beijing Science and Technology Planning Project Z171100001017106National Natural Science Foundation of China 81904194
6 · The paper itself

Abstract

Microglia are immune-competent cells that are critically involved in maintaining normal brain function. A prominent characteristic of Alzheimer disease (AD) is microglial proliferation and activation concentrated around amyloid plaques in the brain. Recent research has revealed numerous microglial phenotypes related to aging and AD, apart from the traditional M1 and M2 types. Redox signalling modulates the acquisition of the classical or alternative microglia activation phenotypes. The numerous microglial functions can be achieved through these multiple phenotypes, which are associated with distinct molecular signatures.

Indexed as

Alzheimer diseaseMicrogliaMicroglia phenotypeNeurodegeneration

Identifiers

PMID36209099
PMCPMC9547462

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.