Evidence map›Paper›PMID 36208391›Full record

ArticleOphthalmology and therapy2022

Investigation of the Efficacy and Safety of 650 nm Low-Level Red Light for Myopia Control in Children: A Randomized Controlled Trial.

Lei Tian, Kai Cao, Dong-Li Ma, Shi-Qiang Zhao, Li-Xin Lu, Ao Li, Chang-Xi Chen, Chun-Rong Ma, Zhang-Fang Ma, Ying Jie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 8 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 8 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  6. Guideline
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  9. Trial
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  12. Review
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  14. Comparison of the efficacy and clinical applications of three different myopia control methods: repeated low-level red light, 1% atropine, and orthokeratology lenses in children and adolescent.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  15. Article
  16. Identifying and Managing Pre-Myopia: A Narrative Review.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Review
  17. Management of myopia: a mini-review.Medical hypothesis, discovery & innovation ophthalmology journal · 2026
    Review
  18. Influence of light on myopia-a review.International journal of ophthalmology · 2026
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Lei Tian *Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, No.17, Hougou Alley, Dongcheng District, Beijing, 100730, China.
Kai Cao *Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, No.17, Hougou Alley, Dongcheng District, Beijing, 100730, China.
Dong-Li MaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Shi-Qiang ZhaoBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Li-Xin LuBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Ao LiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Chang-Xi ChenBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, No.17, Hougou Alley, Dongcheng District, Beijing, 100730, China.
Chun-Rong MaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Zhang-Fang MaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Ying JieBeijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, No.17, Hougou Alley, Dongcheng District, Beijing, 100730, China. jie_yingcn@aliyun.com.ORCID http://orcid.org/0000-0003-2649-8241
Beijing Tongren Hospital · CN

Funding

Capital Health Research and Development of Special 2022-1-1081
6 · The paper itself

Abstract

introductionTo evaluate the 6-month efficacy and safety of 650 nm low-level red light (LLRL) for myopia control in children.

methodsThis was a single-center, single-masked randomized controlled trial. A total of 224 children aged 6-12 years with spherical equivalent error (SER) of - 6 diopter (D) to - 0.5 D were enrolled, and were randomized to LLRL group or control group. Children in the LLRL group underwent treatment twice daily, each lasting for 3 min, there was an interval of at least 4 h between treatments. Children in both groups were allowed to wear single-vision spectacles; no additional intervention was given to the control. The primary outcomes included change in cycloplegic SER and change in axial length (AL) during 6 months.

resultsThe median 6-month changes in AL of the LLRL and control groups were - 0.06 mm (interquartile range, IQR - 0.15, 0) and 0.14 mm (IQR 0.07, 0.22), respectively. The difference between groups was significant (Z = 10.021, p < 0.001). The median 6-month changes in SER were 0.125 D (IQR 0, 0.375) and - 0.25 D (IQR - 0.5, 0) for the LLRL and control groups, respectively. The difference between groups was significant (Z = 8.827, p < 0.001). Compared with the control, the proportion of children with hyperopic shift in the LLRL group was higher (51.65% vs. 3.41%, p < 0.001), and the proportion of children with shortened AL in the LLRL group was higher (63.74% vs. 2.27%, p < 0.001). No adverse event was observed.

conclusion650 nm LLRL significantly slowed down the myopia progression in children aged 6-12 years, and there was no observable side effect in the short term.

Indexed as

ChildrenLow-level red lightMyopiaRandomized controlled trial

Identifiers

PMID36208391
PMCPMC9587157
OpenAlexW4303648670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.