ArticleInternational urogynecology journal2023
Bioinformatically deciphering immune cell infiltration and signature genes in pelvic organ prolapse.
Article in International urogynecology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Thrombospondin-1 as a Mechanosensitive Matrix Protein Driving Fibroblast Senescence: A Novel Pathogenic Target for Pelvic Organ Prolapse.International urogynecology journal · 2026Article
- Raman spectroscopy for nondestructive detection of vaginal tissue alterations in the fibulin-5 murine model of pelvic organ prolapse.Biophotonics discovery · 2026Article
- Transcriptomic and experimental identification of immune- and telomere-related genes in pelvic organ prolapse.Frontiers in pharmacology · 2026Article
- Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026Review
- Comparative analysis reveals distinct molecular heterogeneity in vaginal cells between recurrent and primary pelvic organ prolapse patients.Frontiers of medicine · 2025Article
- Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets.Molecular medicine (Cambridge, Mass.) · 2024Review
- Single-cell analysis of uterosacral ligament revealed cellular heterogeneity in women with pelvic organ prolapse.Communications biology · 2024Article
- Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in pelvic organ prolapse.Frontiers in genetics · 2024Article
- Identification of potential molecular mechanisms and therapeutic targets for recurrent pelvic organ prolapse.Heliyon · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThe study is aimed at bioinformatically deciphering immune cell infiltration, signature genes, and their correlations in POP.
methodsThree microarray datasets were included. Matrixes representing the uterosacral ligament were merged as a test matrix and the others representing vaginal tissues were merged as a validation matrix. The single-sample Gene Set Enrichment Analysis (ssGSEA) algorithm was performed to evaluate immune cell infiltration. Correlations among differential immune cells were revealed by Spearman's rank correlation. Differentially expressed genes (DEGs) were screened by both "Batch correction" and "RobustRankAggreg" methods. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes were conducted for functional analysis. Hub genes were identified through cytoHubba of Cytoscape, and further validated by a validation matrix and clinical samples as signature genes. Correlations of differential immune cells with signature genes were analyzed by Spearman's rank correlation.
resultsFive differential immune cells (macrophages, monocytes, regulatory T cell [Treg], type 1 T cell [Th1], and natural killer T cells [NKT]) were identified and eight pairs of immune cells had significant correlations. Screened 230 DEGs were extracellular matrix (ECM) and immune related. Eleven hub genes were initially identified and five of them (LOX, IL-6, SDC1, ICAM1, and CD38) were validated as signature genes. Significant correlations of differential immune cells with signature genes were shown in twelve pairs, especially Th1-IL6, NKT-IL6, Th1-ICAM1, macrophage-IL6, and macrophage-LOX pairs.
conclusionsPelvic organ prolapse could be considered immune related. Significantly infiltrated immune cells may contribute to the development of POP through close involvement with ECM- and immune-related signature genes.
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