Evidence map›Paper›PMID 36208079›Full record

ArticleAdvanced healthcare materials2022

Cell-Derived Vesicles with Increased Stability and On-Demand Functionality by Equipping Their Membrane with a Cross-Linkable Copolymer.

Xinan Huang, Dimitri Hürlimann, Hendrik T Spanke, Dalin Wu, Michal Skowicki, Ionel Adrian Dinu, Eric R Dufresne, Cornelia G Palivan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Polymerization from Lipid Membranes.Biomacromolecules · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinan HuangDepartment of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, Basel, 4058, Switzerland.ORCID 0000-0001-8538-8486
Dimitri HürlimannDepartment of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, Basel, 4058, Switzerland.ORCID 0000-0002-9605-8498
Hendrik T SpankeLaboratory for Soft and Living Materials, Department of Materials, ETH Zurich, Vladimir-Prelog-Weg 5, Zurich, 8093, Switzerland.ORCID 0000-0002-7584-5011
Dalin WuDepartment of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, Basel, 4058, Switzerland.
Michal SkowickiDepartment of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, Basel, 4058, Switzerland.ORCID 0000-0003-1955-5615
Ionel Adrian DinuDepartment of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, Basel, 4058, Switzerland.ORCID 0000-0002-8208-939X
Eric R DufresneLaboratory for Soft and Living Materials, Department of Materials, ETH Zurich, Vladimir-Prelog-Weg 5, Zurich, 8093, Switzerland.ORCID 0000-0002-3091-5039
Cornelia G PalivanDepartment of Chemistry, University of Basel, BPR1096, Mattenstrasse 24a, Basel, 4058, Switzerland.ORCID 0000-0001-7777-5355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-derived vesicles retain the cytoplasm and much of the native cell membrane composition. Therefore, they are attractive for investigations of membrane biophysics, drug delivery systems, and complex molecular factories. However, their fragility and aggregation limit their applications. Here, the mechanical properties and stability of giant plasma membrane vesicles (GPMVs) are enhanced by decorating them with a specifically designed diblock copolymer, cholesteryl-poly[2-aminoethyl methacrylate-b-poly(ethylene glycol) methyl ether acrylate]. When cross-linked, this polymer brush enhances the stability of the GPMVs. Furthermore, the pH-responsiveness of the copolymer layer allows for a controlled cargo loading/release, which may enable various bioapplications. Importantly, the cross-linked-copolymer GPMVs are not cytotoxic and preserve in vitro membrane integrity and functionality. This effective strategy to equip the cell-derived vesicles with stimuli-responsive cross-linkable copolymers is expected to open a new route to the stabilization of natural membrane systems and overcome barriers to biomedical applications.

Indexed as

PolymersBiophysicsPolymerscross-linkinggiant plasma membrane vesiclesmechanical stabilitymembrane modificationpH-triggered permeability

Identifiers

PMID36208079
PMCPMC11469159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.