Evidence map›Paper›PMID 36208038›Full record

ArticleJournal of sleep research2023

Sleep symptoms are essential features of long-COVID - Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II).

Ilona Merikanto, Yves Dauvilliers, Frances Chung, Yun Kwok Wing, Luigi De Gennaro, Brigitte Holzinger, Bjørn Bjorvatn, Charles M Morin, Thomas Penzel, Christian Benedict and 15 more

Abstract read
In one paragraph

Article in Journal of sleep research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. New-onset Kleine-Levin syndrome following COVID-19 infection: A case report.PCN reports : psychiatry and clinical neurosciences · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Prevalence and associations of insomnia after COVID-19 infection.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  16. Review
  17. Long-term Effects of COVID-19 on Sleep PatternsThoracic research and practice · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ilona MerikantoSleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-1222-6678
Yves DauvilliersSleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, Institute for Neurosciences of Montpellier INM, INSERM, University of Montpellier, Montpellier, France.ORCID 0000-0003-0683-6506
Frances ChungDepartment of Anesthesiology and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Yun Kwok WingLi Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0002-5745-5474
Luigi De GennaroDepartment of Psychology, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-3613-6631
Brigitte HolzingerInstitute for Consciousness and Dream Research, Medical University of Vienna, Wien, Postgraduate Sleep Coaching, Vienna, Austria.
Bjørn BjorvatnDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.ORCID 0000-0001-7051-745X
Charles M MorinCentre de recherche CERVO/Brain Research Center, École de psychologie, Université Laval, Quebec City, Quebec, Canada.
Thomas PenzelSleep Medicine Center, Charite University Hospital Berlin, Berlin, Germany.ORCID 0000-0002-4304-0112
Christian BenedictDepartment of Pharmaceutical Biosciences, Molecular Neuropharmacology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8911-4068
Adrijana Koscec BjelajacInstitute for Medical Research and Occupational Health, Zagreb, Croatia.ORCID 0000-0003-0547-0047
Ngan Yin ChanLi Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Colin A EspieSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0002-1294-8734
Harald Hrubos-StrømDepartment of Otorhinolaryngology, Akershus University Hospital, Lørenskog, Norway.
Yuichi InoueDepartment of Somnology, Tokyo Medical University, Tokyo, Japan.
Maria KormanDepartment of Occupational Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.ORCID 0000-0003-1895-0189
Anne-Marie LandtblomDepartment of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden.
Damien LégerSleep and Vigilance Center, Hopital Hotel-Dieu de Paris, Paris, France.
Kentaro MatsuiDepartment of Clinical Laboratory, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Japan.
Sergio Mota-RolimBrain Institute, Physiology and Behavior Department, Federal University of Rio Grande do Norte, Natal, Brazil.
Michael R NadorffDepartment of Psychology, Mississippi State University, Mississippi State, Mississippi, USA.
Giuseppe PlazziIRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy.ORCID 0000-0002-1051-0472
Catia ReisUniversidade Católica Portuguesa, Católica Research Centre for Psychological-Family and Social Wellbeing, Lisbon, Portugal.
Juliana YordanovaInstitute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Markku PartinenDepartment of Clinical Neurosciences, Clinicum, University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many people report suffering from post-acute sequelae of COVID-19 or "long-COVID", but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18-99 years from 16 countries of Asia, Europe, North America and South America (May-Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute sequelae of COVID-19 has a clinical relevance when diagnosing and treating long-COVID.

Indexed as

COVID-19Disorders of Excessive SomnolenceSleep Initiation and Maintenance DisordersFatigueHumansPost-Acute COVID-19 SyndromeSleepCOVID-19excessive daytime sleepinessfatigueinsomniapandemicpost-acute sequelae of COVID-19

Identifiers

PMID36208038
PMCPMC9874584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.