ArticleCritical care (London, England)2022
Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors.
Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01367093 (French and EuRopean Outcome Registry in Intensive Care Unit), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
French and EuRopean Outcome Registry in Intensive Care Unit
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Restrictive vs. Liberal Transfusion Strategy in Critically Ill Patients with Acute Brain Injury: A Systematic Review and Meta-analysis.Neurocritical care · 2026Pooled it
- Restrictive vs Liberal Transfusion Strategy in Traumatic Brain Injury: A Secondary Analysis of the TRAIN Trial.JAMA network open · 2026Trial
- Trial
- Timing of Transfusion Strategy Initiation in Acute Brain Injury: A Subanalysis of the TRAIN Study.Neurocritical care · 2026Article
- Association between early red blood cell transfusion after return of spontaneous circulation and clinical outcomes in cardiac arrest patients.Scientific reports · 2026Article
- Liberal Versus Restrictive Blood Transfusion Strategies in Neurocritical Care: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Critical care research and practice · 2026Article
- Molecular Mechanisms of Transfusion-Associated Immunomodulation and Its Impact in the Critically Ill.International journal of molecular sciences · 2025Review
- Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis.Critical care (London, England) · 2025Observational
- A Comprehensive Review of Fluid Resuscitation Strategies in Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data.Critical care (London, England) · 2025Observational
- Transfusion probability as an alternative measure of lab-guided medical decision-making.Transfusion · 2025Article
- Mortality in Critically Ill Patients with Liberal Versus Restrictive Transfusion Thresholds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis.Journal of clinical medicine · 2025Review
- Cost Reduction in Blood Transfusions After Implementation of Decision Protocol Based on Hemoglobin and Anemia Symptoms: A Pre-Post Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Transfusion and Mortality in Acute Care Surgical Patients in Malawi: A Propensity-Matched Analysis.The Journal of surgical research · 2024Article
- Anti-inflammatory therapies are associated with delayed onset of anemia and reduction in transfusion requirements in critically ill patients: results from two studies.Critical care (London, England) · 2024Observational
- Ultra-restrictive red blood cell transfusion strategies in extensively burned patients.Scientific reports · 2024Article
- Response to "Not All Grams per Deciliter of Hemoglobin Are Equal".Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Blood transfusion is correlated with elevated adult all-cause mortality and cardiovascular mortality in the United States: NHANES 1999 to 2018 population-based matched propensity score study.Clinics (Sao Paulo, Brazil) · 2024Article
- A simple program to improve the appropriateness of red blood cell transfusions in non-bleeding hospital patients: a before-and-after study.Archives of medical science : AMS · 2024Article
- Norepinephrine and Vasopressin in Hemorrhagic Shock: A Focus on Renal Hemodynamics.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
23 authors at 17 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpact of in-ICU transfusion on long-term outcomes remains unknown. The purpose of this study was to assess in critical-care survivors the association between in-ICU red blood cells transfusion and 1-year mortality.
methodsFROG-ICU, a multicenter European study enrolling all-comers critical care patients was analyzed (n = 1551). Association between red blood cells transfusion administered in intensive care unit and 1-year mortality in critical care survivors was analyzed using an augmented inverse probability of treatment weighting-augmented inverse probability of censoring weighting method to control confounders.
resultsAmong the 1551 ICU-survivors, 42% received at least one unit of red blood cells while in intensive care unit. Patients in the transfusion group had greater severity scores than those in the no-transfusion group. According to unweighted analysis, 1-year post-critical care mortality was greater in the transfusion group compared to the no-transfusion group (hazard ratio (HR) 1.78, 95% CI 1.45-2.16). Weighted analyses including 40 confounders, showed that transfusion remained associated with a higher risk of long-term mortality (HR 1.21, 95% CI 1.06-1.46).
conclusionsOur results suggest a high incidence of in-ICU RBC transfusion and that in-ICU transfusion is associated with a higher 1-year mortality among in-ICU survivors. Trial registration ( NCT01367093 ; Registered 6 June 2011).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.