Evidence map›Paper›PMID 36207652›Full record

ArticleJournal of autism and developmental disorders2023

Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia.

Sarah M Haigh, Laura Van Key, Pat Brosseau, Shaun M Eack, David I Leitman, Dean F Salisbury, Marlene Behrmann

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses.Autism research : official journal of the International Society for Autism Research · 2026
    Pooled it
  2. On variability in local field potentials.Communications biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Forwarding the Science of Sensory Features in Autism and Related Conditions.Journal of autism and developmental disorders · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah M HaighDepartment of Psychology and Center for Integrative Neuroscience, University of Nevada, Reno, Reno, NV, USA. shaigh@unr.edu.ORCID http://orcid.org/0000-0003-2400-4412
Laura Van KeyDepartment of Psychology and Center for Integrative Neuroscience, University of Nevada, Reno, Reno, NV, USA.
Pat BrosseauDepartment of Psychology and the Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Shaun M EackSchool of Social Work, University of Pittsburgh, Pittsburgh, PA, USA.
David I LeitmanNational Institute of Mental Health, Bethesda, MD, USA.
Dean F SalisburyDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Marlene BehrmannDepartment of Psychology and the Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA.

Funding

Biomarkers of auditory processing in schizophrenia: do they reflect symptom severity? An investigation in schizotypyR15MH122935 · NIMH · UNIVERSITY OF NEVADA RENO · PI BERRYHILL, MARIAN E, HAIGH, SARAH M · 2020 to 2022
$424k
NIMH NIH HHS 122935NIMH NIH HHS R15 MH122935
6 · The paper itself

Abstract

Sensory abnormalities are characteristic of autism and schizophrenia. In autism, greater trial-to-trial variability (TTV) in sensory neural responses suggest that the system is more unstable. However, these findings have only been identified in the amplitude and not in the timing of neural responses, and have not been fully explored in schizophrenia. TTV in event-related potential amplitudes and inter-trial coherence (ITC) were assessed in the auditory mismatch negativity (MMN) in autism, schizophrenia, and controls. MMN was largest in autism and smallest in schizophrenia, and TTV was greater in autism and schizophrenia compared to controls. There were no differences in ITC. Greater TTV appears to be characteristic of both autism and schizophrenia, implicating several neural mechanisms that could underlie sensory instability.

Indexed as

Autism Spectrum DisorderAutistic DisorderSchizophreniaAcoustic StimulationElectroencephalographyEvoked PotentialsEvoked Potentials, AuditoryHumansAuditoryAutismEvent-related potentialsInter-trial coherenceSchizophreniaTrial-to-trial variability

Identifiers

PMID36207652
PMCPMC10079782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.