Evidence map›Paper›PMID 36207558›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2023

Inefficient diastolic filling in dual-chamber pacemaker recipients: impact of atrio-ventricular interval shortening (AVI-SHORT study).

Damia Pereferrer, Axel Sarrias, Raquel Adeliño, Felipe Bisbal, Júlia Aranyó, Nuria Vallejo, Roger Villuendas, Antoni Bayes-Genis, Victor Bazan

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In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Damia PereferrerCardiology Department, Hospital Universitari Germans Trias I Pujol, Badalona, s/n Carretera de Canyet, 08916, Barcelona, Spain.
Axel SarriasCardiology Department, Hospital Universitari Germans Trias I Pujol, Badalona, s/n Carretera de Canyet, 08916, Barcelona, Spain.
Raquel AdeliñoCardiology Department, Hospital Universitari Germans Trias I Pujol, Badalona, s/n Carretera de Canyet, 08916, Barcelona, Spain.
Felipe BisbalCardiology Department, Hospital Universitari Germans Trias I Pujol, Badalona, s/n Carretera de Canyet, 08916, Barcelona, Spain.
Júlia AranyóCardiology Department, Hospital Universitari Germans Trias I Pujol, Badalona, s/n Carretera de Canyet, 08916, Barcelona, Spain.
Nuria VallejoCardiology Department, Hospital Universitari Germans Trias I Pujol, Badalona, s/n Carretera de Canyet, 08916, Barcelona, Spain.
Roger VilluendasCardiology Department, Hospital Universitari Germans Trias I Pujol, Badalona, s/n Carretera de Canyet, 08916, Barcelona, Spain.
Antoni Bayes-GenisCardiology Department, Hospital Universitari Germans Trias I Pujol, Badalona, s/n Carretera de Canyet, 08916, Barcelona, Spain.
Victor BazanCardiology Department, Hospital Universitari Germans Trias I Pujol, Badalona, s/n Carretera de Canyet, 08916, Barcelona, Spain. victorbazang@yahoo.com.ORCID http://orcid.org/0000-0001-8072-7434
Universitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdequate synchronization between the passive ("E") and active ("a") left ventricular (LV) diastolic filling contributes to the efficiency of the heartbeat. E/a superposition in dual-chamber pacemaker (PM) recipients is an under-recognized phenomenon that may be corrected by shortening the atrio-ventricular interval (AVI). We aimed at establishing the prevalence of E/a superposition in PM patients and to analyze the clinical, echocardiographic, and biological impact of AVI shortening.

methodsSeventy patients with dual-chamber PMs (74 ± 8 years old, 12 women) were consecutively enrolled in this study. Patients with baseline E/a superposition were crossed over from default to manually shortened AVI or vice versa in a case-control fashion (intervention group). Patients without baseline E/a superposition (controls) served as a reference for a descriptive comparison with the intervention group.

resultsThirty-three patients had E/a superposition after PM implantation (47%). Controls (n = 37) had higher LV ejection fraction (59 ± 8% vs. 53 ± 10%, p = 0.048) and lower levels of high sensitive troponin T and ST2 (p < 0.05) than intervention group patients. The AVI was shortened at 48 ± 9 ms in order to ensure adequate E/a separation. The walked distance increased from 75 ± 17 to 78 ± 10% (p = 0.049) and the Euro-QoL score from 0.50 ± 0.27 to 0.63 ± 0.19 (p = 0.011) with short AVI.

conclusionsE/a superposition occurs in approximately half of dual-chamber PM recipients and is associated with reduced LV function and increased myocardial injury biomarkers. AVI shortening produces a modest but significant effect in functional capacity and quality of life.

Indexed as

Pacemaker, ArtificialQuality of LifeAgedAged, 80 and overCardiac Pacing, ArtificialDiastoleFemaleHumansVentricular Function, LeftAV intervalDual-chamber pace-makerE/a superpositionTrans-mitral filling

Identifiers

PMID36207558
OpenAlexW4303520832

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.