ArticleScientific reports2022
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
10.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Identifying novel gene dysregulation associated with opioid overdose death: a meta-analysis of differential gene expression in human prefrontal cortex.Translational psychiatry · 2026Pooled it
- Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.Molecular psychiatry · 2022Pooled it
- Reln Haploinsufficiency Enhances Fentanyl-Induced Locomotion and Dorsal Striatal Activity Without Affecting Opioid Reinforcement and Relapse-Like Behavior.Genes, brain, and behavior · 2026Article
- Article
- Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G.Nature communications · 2026Article
- Regulatory mechanisms driven by functional 3'-UTR variants in alcohol use disorder and related traits.Genome biology · 2026Article
- Exploring the genetic overlap between substance use disorder and educational attainment.Addiction (Abingdon, England) · 2026Article
- Reln haploinsufficiency enhances fentanyl-induced locomotion and striatal activity without affecting opioid reinforcement and relapse-like behavior.bioRxiv : the preprint server for biology · 2026Article
- Deciphering the impact of genetic variants on vulnerability to Opioid Use Disorder.Frontiers in cellular neuroscience · 2026Article
- Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases.Translational psychiatry · 2025Article
- Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.Translational psychiatry · 2025Article
- Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.Nature genetics · 2025Article
- Gene expression differences in differentially methylated sites associated with HIV status and cocaine use.Clinical and translational medicine · 2025Article
- Exploring the implications of case selection methods for psychiatric molecular genetic studies.Molecular psychiatry · 2025Article
- Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty.Research square · 2025Article
- Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms.Drug and alcohol dependence · 2025Article
- Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty.medRxiv : the preprint server for health sciences · 2025Article
- Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction.Biological psychiatry · 2025Article
- Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains.Biological psychiatry global open science · 2025Article
- Prenatal cannabis exposure is associated with alterations in offspring DNA methylation at genes involved in neurodevelopment, across the life course.Molecular psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 20 institutions in 3 countries.
Nathan Gaddis *GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Ravi Mathur *GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Jesse MarksGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Linran ZhouGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Bryan QuachGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Alex WaldropGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Orna LevranThe Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Matthew RandesiThe Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.
Miriam AdelsonDr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse, Treatment and Research, Las Vegas, NV, USA.
Paul W JeffriesDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Louisa DegenhardtNational Drug and Alcohol Research Centre, University of New South Wales, Randwick, NSW, Australia.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Leah WetherillMedical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Dongbing LaiMedical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Kathleen BucholzDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Tatiana ForoudMedical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Bernice PorjeszDepartment of Psychiatry, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
Valgerdur RunarsdottirSAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Thorarinn TyrfingssonSAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Gudmundur EinarssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Daniel F GudbjartssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Bradley Todd WebbGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Richard C CristDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Richard ShervaGenome Science Institute, Boston University, Boston, MA, USA.
Hang ZhouDepartment of Psychiatry, Yale University School of Medicine, West Haven, CT, USA.
Gary HulseSchool of Psychiatry and Clinical Neurosciences, The University of Western Australia, Perth, WA, Australia.
Dieter WildenauerSchool of Psychiatry and Clinical Neurosciences, The University of Western Australia, Perth, WA, Australia.
Erin KeltySchool of Population and Global Health, Population and Public Health, The University of Western Australia, Perth, WA, Australia.
John AttiaHunter Medical Research Institute, Newcastle, Australia.
Elizabeth G HollidayHunter Medical Research Institute, Newcastle, Australia.
Mark McEvoyHunter Medical Research Institute, Newcastle, Australia.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy College of Health, Medicine and Wellbeing, The University of Newcastle, New Lambton Heights, NSW, Australia.
Sibylle G SchwabFaculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia.
Brion S MaherDepartment of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Richard GruzaDepartment of Family and Community Medicine, Saint Louis University, Saint Louis, MO, USA.
Mary Jeanne KreekThe Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA.
Elliot C NelsonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Thorgeir ThorgeirssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Wade H BerrettiniDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Joel GelernterDepartment of Psychiatry, Genetics, & Neuroscience, Yale University School of Medicine, West Haven, CT, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Laura BierutDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
Dana B HancockGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA.
Eric Otto Johnson *GenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA. ejohnson@rti.org.
RTI International · USWashington University in St. Louis · USdeCODE Genetics (Iceland) · ISRockefeller University · USUniversity of Pennsylvania · USUniversity of Western Australia · AUHunter Medical Research Institute · AUIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineSociety of Alcoholism and other Addictions · ISUniversity of Newcastle Australia · AUYale University · USBoston University · USJohns Hopkins University · USQIMR Berghofer Medical Research Institute · AUSaint Louis University · USState University of New York · USUniversity of Iceland · ISUniversity of Queensland · AUUniversity of Wollongong · AU
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTRANSFORMING TRANSLATIONAL SCIENCE AND EDUCATION TO BENEFIT HUMAN HEALTHUL1RR024143 · NCRR · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2006 to 2011
$49.1MSynergy Core (SynC)P50DA054071 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI Daniel A Jacobson · 2022 to 2026
$13.1MNJ Methadone Maintenance Subject Recruitment for Genomic Analyses and Repository ExpansionR01DA044014 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JOHNSON, ERIC OTTO · 2017 to 2021
$4.2MEnhancing Discovery of HIV Host Genetics using Drug Abuse and other InteractionsR01DA038632 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JOHNSON, ERIC OTTO · 2014 to 2018
$3.7MGenome-Wide Association Study of Heroin Abuse: A Multiethnic StudyR33DA027486 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI JOHNSON, ERIC OTTO · 2011 to 2012
$803kThe role of the delta-opioid receptor gene, OPRD1, in opioid addiction treatmentK01DA036751 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI CRIST, RICHARD C. · 2014 to 2018
$717kNCATS NIH HHS UL1RR024143NCATS NIH HHS UL1 TR001863NCRR NIH HHS UL1 RR024143NIAAA NIH HHS U10 AA008401NIAAA NIH HHS U10AA008401NIDA NIH HHS K01 DA036751NIDA NIH HHS K01DA036751NIDA NIH HHS P50 DA054071NIDA NIH HHS R01 DA038632NIDA NIH HHS R01DA038632NIDA NIH HHS R01DA04401NIDA NIH HHS R01 DA044014NIDA NIH HHS R01DA044014NIDA NIH HHS R33 DA027486NIDA NIH HHS R33DA027486
Abstract
Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in OPRM1, has been identified as a genome-wide significant association with OA and independently replicated. We applied genomic structural equation modeling to conduct a GWAS of the new Genetics of Opioid Addiction Consortium (GENOA) data together with published studies (Psychiatric Genomics Consortium, Million Veteran Program, and Partners Health), comprising 23,367 cases and effective sample size of 88,114 individuals of European ancestry. Genetic correlations among the various OA phenotypes were uniformly high (r
Indexed as
Genome-Wide Association StudyOpioid-Related DisordersFurinGenetic Predisposition to DiseaseHumansPhenotypePolymorphism, Single NucleotideReceptors, Opioid, muFurinOPRM1 protein, humanReceptors, Opioid, mu
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