Evidence map›Paper›PMID 36207171›Full record

ArticleTrends in neurosciences2023

Thalamic pathways mediating motor and non-motor symptoms in a Parkinson's disease model.

Bin Xiao, Eng-King Tan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Bin XiaoDepartment of Neurology, National Neuroscience Institute, Singapore.
Eng-King TanDepartment of Neurology, National Neuroscience Institute, Singapore; Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore. Electronic address: gnrtek@sgh.com.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a recent study, Zhang, Roy, and colleagues have shown that neurons in the parafascicular (PF) thalamus project to three distinct neural structures in the basal ganglia. The neural circuits identified in the study were associated with specific motor and non-motor symptoms in a Parkinson's disease (PD) mouse model. The findings provide potential actionable therapeutic targets for this disease.

Indexed as

Deep Brain StimulationParkinson DiseaseAnimalsBasal GangliaDisease Models, AnimalMiceNeural PathwaysNeuronsThalamusbasal gangliadeep brain stimulationnicotinic acetylcholine receptorssubthalamic nucleusthalamus

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.