ArticleThe Journal of thoracic and cardiovascular surgery2024
The predictive capability of aortic stiffness index for aortic dissection among dilated ascending aortas.
Article in The Journal of thoracic and cardiovascular surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Radiographic phenotyping of healthy and diseased aortas.Journal of cardiovascular imaging · 2026Article
- Role of aortic distensibility and stiffness in ascending thoracic aneurysm outcomes.JTCVS open · 2025Article
- Ascending Aortic Aneurysms: From Pathophysiology to Surgical Repair.Journal of clinical medicine · 2025Review
- Wall Tensile Stress Maps of Human Aneurysmal Aorta Demonstrate a High Biaxiality Ratio Corresponds with Wall Tissue Microstructure and Local Oxidative Stress Response Distinctly for Bicuspid and Tricuspid Aortic Valve Patients.Annals of biomedical engineering · 2025Article
- Sex-related differences in the clinical course of aortic root and ascending aortic aneurysms: the DisSEXion Study.European heart journal · 2025Article
- Non-invasive estimation of material properties of normal and dissected human ascending aortasFrontiers in bioengineering and biotechnology · 2025Article
- Age- and sex-specific biomechanics and extracellular matrix remodeling of the ascending aorta in a mouse model of severe Marfan syndrome.American journal of physiology. Heart and circulatory physiology · 2024Article
- Stiffness matters: Improved failure risk assessment of ascending thoracic aortic aneurysms.JTCVS open · 2023Article
- Noninvasive left ventricular pressure-strain myocardial work in patients with well-functioning bicuspid aortic valves and aortic dilation: a preliminary study.Quantitative imaging in medicine and surgery · 2023Article
- The Role of Spatial Aortic Arch Architecture in Type B Aortic Dissection.Journal of clinical medicine · 2023Article
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Abstract
objectiveWe created a finite element model to predict the probability of dissection based on imaging-derived aortic stiffness and investigated the link between stiffness and wall tensile stress using our model.
methodsTransthoracic echocardiogram measurements were used to calculate aortic diameter change over the cardiac cycle. Aortic stiffness index was subsequently calculated based on diameter change and blood pressure. A series of logistic models were developed to predict the binary outcome of aortic dissection using 1 or more series of predictor parameters such as aortic stiffness index or patient characteristics. Finite element analysis was performed on a subset of diameter-matched patients exhibiting patient-specific material properties.
resultsTransthoracic echocardiogram scans of patients with type A aortic dissection (n = 22) exhibited elevated baseline aortic stiffness index when compared with aneurysmal patients' scans with tricuspid aortic valve (n = 83, P < .001) and bicuspid aortic valve (n = 80, P < .001). Aortic stiffness index proved an excellent discriminator for a future dissection event (area under the curve, 0.9337, odds ratio, 2.896). From the parametric finite element study, we found a correlation between peak longitudinal wall tensile stress and stiffness index (ρ = .6268, P < .001, n = 28 pooled).
conclusionsNoninvasive transthoracic echocardiogram-derived aortic stiffness measurements may serve as an impactful metric toward predicting aortic dissection or quantifying dissection risk. A correlation between longitudinal stress and stiffness establishes an evidence-based link between a noninvasive stiffness parameter and stress state of the aorta with clinically apparent dissection events.
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