Evidence map›Paper›PMID 36207141›Full record

ReviewGenes & development2022

A protein synthesis brake for hematopoietic stem cell maintenance.

Kaosheng Lv, Wei Tong

Open access · diamondAbstract readReview
In one paragraph

Review in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. 8-Me-PIQ Expands Cord Blood CD34Stem cell reviews and reports · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Kaosheng LvDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518000, China.
Wei TongChildren's Hospital of Philadelphia; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Southern University of Science and Technology · CNUniversity of Pennsylvania · US

Funding

Regulation of Ribosome Biogenesis in Hematopoietic Stem CellsR01DK127738 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI TONG, WEI · 2020 to 2024
$3.0M
Novel Regulation of Oncogenic NRAS Signaling in Myeloid MalignanciesR01CA271523 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Wei Tong · 2022 to 2026
$2.7M
NCI NIH HHS R01 CA271523NIDDK NIH HHS R01 DK127738
6 · The paper itself

Abstract

Bmi1 is essential for normal and leukemic hematopoiesis, but its target genes in hematopoietic stem cells (HSCs) are incompletely understood. In this issue of

Indexed as

Polycomb Repressive Complex 1Proto-Oncogene ProteinsCyclin-Dependent Kinase Inhibitor p16HematopoiesisHematopoietic Stem CellsCyclin-Dependent Kinase Inhibitor p16Polycomb Repressive Complex 1Proto-Oncogene Proteinspolycombself-renewalsenescencetissue regenerationtumor suppressor

Identifiers

PMID36207141
PMCPMC9575693
OpenAlexW4303685027

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.