Evidence map›Paper›PMID 36207110›Full record

ArticleOccupational and environmental medicine2022

Herbicide use in farming and other jobs in relation to non-Hodgkin's lymphoma (NHL) risk.

Anneclaire J De Roos, Lin Fritschi, Mary H Ward, Alain Monnereau, Jonathan Hofmann, Leslie Bernstein, Parveen Bhatti, Yolanda Benavente Moreno, Geza Benke, Delphine Casabonne and 13 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Occupational and environmental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 8 countries.

Anneclaire J De RoosDepartment of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA aderoos@drexel.edu.ORCID 0000-0002-2811-2405
Lin FritschiSchool of Population Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0002-7692-3560
Mary H WardOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Alain MonnereauRegistre des Hémopathies Malignes de la Gironde, Institut Bergonié, University of Bordeaux, Bordeaux, France.
Jonathan HofmannOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Leslie BernsteinDivision of Biomarkers of Early Detection and Prevention, Beckman Research Institute of City of Hope, City of Hope Comprehensive Cancer Center, Duarte, California, USA.
Parveen BhattiCancer Control Research, BC Cancer, Vancouver, British Columbia, Canada.
Yolanda Benavente MorenoCancer Epidemiology Research Program, Institut Català d'Oncologia (ICO)/Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0003-1422-4614
Geza BenkeDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Delphine CasabonneCancer Epidemiology Research Program, Institut Català d'Oncologia (ICO)/Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Jacqueline ClavelEpidemiology of Childhood and Adolescent Cancers Group, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), INSERM, Paris, France.
Pierluigi CoccoCentre for Occupational and Environmental Health, Division of Population Health, University of Manchester, Manchester, UK.ORCID 0000-0001-8256-7614
Tran HuynhDepartment of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA.
Andrea 't MannetjeCentre for Public Health Research, Massey University, Wellington, New Zealand.
Lucia MiligiEnvironmental and Occupational Epidemiology Branch, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Sara PiroEnvironmental and Occupational Epidemiology Branch, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Nathaniel RothmanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Leah H SchinasiDepartment of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8930-9896
Claire M VajdicThe Kirby Institute, University of New South Wales, Kensington, New South Wales, Australia.
Sophia S WangDivision of Health Analytics, Department of Computational and Quantitative Medicine, City of Hope Comprehensive Cancer Center, Duarte, California, USA.
Yawei ZhangNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Susan L SlagerDepartment of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, Minnesota, USA.
James R CerhanDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Drexel University · USNational Institutes of Health · USCity of Hope · USInstituto de Salud Carlos III · ESMayo Clinic · USChinese Academy of Medical Sciences & Peking Union Medical College · CNCurtin University · AUInserm · FRMassey University · NZMonash University · AUUniversité de Bordeaux · FRUniversity of Cagliari · ITUNSW Sydney · AU

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI LENTZ, STEVEN R · 2002 to 2021
$45.7M
Molecular Epidemiology of NHL and CLLR01CA092153 · NCI · MAYO CLINIC ROCHESTER · PI CERHAN, JAMES R · 2003 to 2012
$6.7M
Occupational Pesticide Use and Risk of Lymphoid CancersR03CA199515 · NCI · DREXEL UNIVERSITY · PI DE ROOS, ANNECLAIRE J · 2015 to 2016
$157k
NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA097274NCI NIH HHS R01 CA092153NCI NIH HHS R03 CA199515
6 · The paper itself

Abstract

objectivesGiven mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk of non-Hodgkin's lymphoma (NHL) in a large, pooled study.

methodsWe pooled data from 10 case-control studies participating in the International Lymphoma Epidemiology Consortium, including 9229 cases and 9626 controls from North America, the European Union and Australia. Herbicide use was coded from self-report or by expert assessment in the individual studies, for herbicide groups (eg, phenoxy herbicides) and active ingredients (eg, 2,4-dichlorophenoxyacetic acid (2,4-D), glyphosate). The association between each herbicide and NHL risk was estimated using logistic regression to produce ORs and 95% CIs, with adjustment for sociodemographic factors, farming and other pesticides.

resultsWe found no substantial association of all NHL risk with ever-use of any herbicide (OR=1.10, 95% CI: 0.94 to 1.29), nor with herbicide groups or active ingredients. Elevations in risk were observed for NHL subtypes with longer duration of phenoxy herbicide use, such as for any phenoxy herbicide with multiple myeloma (>25.5 years, OR=1.78, 95% CI: 0.74 to 4.27), 2,4-D with diffuse large B-cell lymphoma (>25.5 years, OR=1.47, 95% CI: 0.67 to 3.21) and other (non-2,4-D) phenoxy herbicides with T-cell lymphoma (>6 years, lagged 10 years, OR=3.24, 95% CI: 1.03 to 10.2). An association between glyphosate and follicular lymphoma (lagged 10 years: OR=1.48, 95% CI: 0.98 to 2.25) was fairly consistent across analyses.

conclusionsMost of the herbicides examined were not associated with NHL risk. However, associations of phenoxy herbicides and glyphosate with particular NHL subtypes underscore the importance of estimating subtype-specific risks.

Indexed as

HerbicidesLymphoma, Non-HodgkinOccupational ExposurePesticidesAgricultureCase-Control StudiesHumansRisk FactorsHerbicidesPesticidesepidemiologyoccupational healthpesticides

Identifiers

PMID36207110
PMCPMC9669193
OpenAlexW4303453867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.