Evidence map›Paper›PMID 36206822›Full record

ArticleBehavioural brain research2023

Neural underpinnings of expecting alcohol: Placebo alcohol administration alters nucleus accumbens resting state functional connectivity.

D E Kirsch, V Le, R Kosted, K Fromme, E T C Lippard

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04063384 (Subjective Response to Alcohol and Associated Neural Systems in Bipolar Disorder), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04063384 nacompletednot on this map

Subjective Response to Alcohol and Associated Neural Systems in Bipolar Disorder

TypeinterventionalSponsorUniversity of Texas at AustinRan2019 to 2024Enrolled60ConditionsBipolar Disorder, Alcohol Drinking, Alcohol Use DisorderArmsalcohol beverage, Placebo beverage
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

D E KirschDepartment of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA; Institute for Neuroscience, University of Texas, Austin, TX, USA. Electronic address: dylankirsch@utexas.edu.
V LeDepartment of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas, Austin, TX, USA.
R KostedDepartment of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas, Austin, TX, USA.
K FrommeWaggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA; Department of Psychology, University of Texas, Austin, TX, USA.
E T C LippardDepartment of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA; Institute for Neuroscience, University of Texas, Austin, TX, USA; Department of Psychology, University of Texas, Austin, TX, USA; Institute of Early Life Adversity Research, University of Texas, Austin, TX, USA. Electronic address: elizabeth.lippard@austin.utexas.edu.
The University of Texas at Austin · US

Funding

Biological Risk Factors for the Prospective Development of Alcohol Use Disorders in Young Adults with Bipolar Disorder and Typically Developing Young AdultsR01AA030038 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI Elizabeth Thomas Cox Lippard · 2023 to 2026
$2.5M
Genetic Mechanisms of Change in Trajectories of Drinking and Deviant BehaviorsR01AA020637 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI FROMME, KIM · 2012 to 2016
$2.3M
Subjective Response to Alcohol and Associated Neural Systems in Bipolar DisorderK01AA027573 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI LIPPARD, ELIZABETH THOMAS COX · 2019 to 2022
$716k
Dissecting Responses to Alcohol in Individuals with Familial Risk for Bipolar DisorderR21AA027884 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI LIPPARD, ELIZABETH THOMAS COX · 2020 to 2021
$416k
Ventral Prefrontal Network Connectivity and Alcohol Sensitivity in Bipolar Disorder and Typically Developing Young AdultsF31AA029005 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI KIRSCH, DYLAN E · 2022 to 2022
$20k
NIAAA NIH HHS F31 AA029005NIAAA NIH HHS K01 AA027573NIAAA NIH HHS R01 AA020637NIAAA NIH HHS R01 AA030038NIAAA NIH HHS R21 AA027884
6 · The paper itself

Abstract

backgroundUsing balanced placebo designs, seminal alcohol administration research has shown individuals' beliefs about whether they have consumed alcohol, irrespective of the actual presence of alcohol, can determine level of alcohol consumption and impact social behavior. Despite the known effect of expecting alcohol on drinking behavior, few studies have used the placebo manipulation to directly investigate the neural underpinnings of the expectancy-related effects that occur following perceived alcohol consumption in humans. The present paper examined placebo responses in the laboratory to better understand the neural basis for the psychological phenomenon of expectancies.

methodsAs part of a larger within-subjects study design, healthy young adults (N = 22, age

resultsCompared to pre-beverage scan, placebo beverage consumption was associated with increased positive functional connectivity between right nucleus accumbens - ventromedial prefrontal cortex and subcallosal cingulate cortex (p

conclusionResults suggest placebo response to alcohol is associated with increased functional connectivity within a key reward network (nucleus accumbens - ventromedial prefrontal cortex and subcallosal cingulate cortex) and put forth a mechanism by which alcohol expectancies may contribute to the subjective experience of intoxication.

Indexed as

EthanolNucleus AccumbensAlcohol DrinkingHumansMagnetic Resonance ImagingNeural PathwaysPrefrontal CortexYoung AdultEthanolAlcohol drinkingFunctional neuroimagingNucleus accumbensPlacebo effectPrefrontal cortexReward

Identifiers

PMID36206822
PMCPMC10955555
OpenAlexW4300981253

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.