Evidence map›Paper›PMID 36206761›Full record

SynthesisHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme2022

Association Of Blood Lipocalin-2 Levels with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Jing Zhu, Shuai Jiang, Xiaohong Jiang, Kaiming Luo, Xiaolin Huang, Fei Hua

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jing Zhu *Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China.
Shuai Jiang *Department of Emergency Medicine, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, China.
Xiaohong JiangDepartment of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China.
Kaiming LuoDepartment of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China.
Xiaolin HuangDepartment of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China.
Fei HuaDepartment of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China.
Soochow University · CNBlood Center of Zhejiang Province · CN

Funding

81900768 Natural Science Foundation of ChinaF201803 General Project of Maternal and Child Health Research Project of Jiangsu ProvinceQN202018 This study was funded by Changzhou Health Commission Young Talents Project
6 · The paper itself

Abstract

Lipocalin-2 (LCN2) is becoming recognized as a pleiotropic mediator of metabolic disorders. However, the relationship between LCN2 and gestational diabetes mellitus (GDM) is not well understood. We performed a systematic review and meta-analysis to explore it. A systematic search of Cochrane Library, PubMed, Embase, Scopus, Web of Science, Chinese National Knowledge Infrastructure, and Wan-fang Database was done for relevant articles published up to September 29, 2021. Standardized mean difference (SMD) with 95% confidence intervals (CI) was calculated to explore the association of LCN2 levels with GDM using Revman 5.3 and Stata 15.1. Fifteen case-control studies were included in this meta-analysis. The patients with GDM had significantly higher levels of blood LCN2 than parturients with normal glucose tolerance (SMD=3.41, 95% CI=2.24 to 4.58). Meta-regression and subgroup analysis were conducted to investigate the source of heterogeneity. Likely sources of heterogeneity were age and testing methods. This study found that GDM showed higher blood LCN2 levels than controls. However, caution is warranted on the interpretation of these findings. Standardized LCN2 measurement methods and longitudinal studies are required to disentangle and better understand the relationships observed.

Indexed as

Diabetes, GestationalCase-Control StudiesFemaleGlucoseHumansLipocalin-2PregnancyGlucoseLCN2 protein, humanLipocalin-2

Identifiers

PMID36206761
PMCPMC9546583
OpenAlexW4303473155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.