ArticleCell reports. Medicine2022
Space-time-regulated imaging analyzer for smart coagulation diagnosis.
Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Optical Biosensors for Blood Coagulation Monitoring: Advantages, Limitations, and Translational Potential.Biosensors · 2026Review
- Advances in hemostatic biomaterials: biomimetic strategies, nanotechnology, and smart therapeutics.Burns & trauma · 2026Review
- [Research progress on point-of-care testing of blood biochemical indexes based on microfluidic technology].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- Random Lasing for Bimodal Imaging and Detection of Tumor.Biosensors · 2023Article
- A microfluidic hemostatic diagnostics platform: Harnessing coagulation-induced adaptive-bubble behavioral perception.Cell reports. Medicine · 2023Article
- Design and Fabrication of a Fully-Integrated, Miniaturised Fluidic System for the Analysis of Enzyme Kinetics.Micromachines · 2023Article
- Portable Prussian Blue-Based Sensor for Bacterial Detection in Urine.Sensors (Basel, Switzerland) · 2022Article
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Authors and funding
16 authors.
Funding
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Abstract
The development of intelligent blood coagulation diagnoses is awaited to meet the current need for large clinical time-sensitive caseloads due to its efficient and automated diagnoses. Herein, a method is reported and validated to realize it through artificial intelligence (AI)-assisted optical clotting biophysics (OCB) properties identification. The image differential calculation is used for precise acquisition of OCB properties with elimination of initial differences, and the strategy of space-time regulation allows on-demand space time OCB properties identification and enables diverse blood function diagnoses. The integrated applications of smartphones and cloud computing offer a user-friendly automated analysis for accurate and convenient diagnoses. The prospective assays of clinical cases (n = 41) show that the system realizes 97.6%, 95.1%, and 100% accuracy for coagulation factors, fibrinogen function, and comprehensive blood coagulation diagnoses, respectively. This method should enable more low-cost and convenient diagnoses and provide a path for potential diagnostic-markers finding.
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