ArticleMolecular cell2022
Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex.
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Article in Molecular cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
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Who cites it
33 citing papers in PubMed, 42 citations in OpenAlex.
- Asymmetric distribution of mitochondrial CaExperimental & molecular medicine · 2026Article
- Mechanistic Modeling of MCUx Gatekeeping, CaAmerican journal of physiology. Cell physiology · 2026Article
- Elevated mitochondrial CaStem cell reports · 2026Article
- The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026Review
- Metal-dependent regulated cell death: Molecular architecture and translational frontiers.iMeta · 2026Review
- New insights on the mechanism of L-arginine in alleviating hepatopancreatic lipid accumulation in grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation.Nature communications · 2026Article
- Reconstructing calcium conductance in MCUb illuminates its molecular design for tuning the mitochondrial calcium uniporter.Nature communications · 2026Article
- MICU proteins facilitate calcium-dependent mitochondrial metabolon formation to regulate cellular energetics independently of MCU.Nature metabolism · 2026Article
- MICU2 controls mitochondrial calcium signaling and migration in neurons during development.Cell reports · 2025Article
- Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles.Circulation research · 2025Article
- Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025Review
- TMEM65 functions as the mitochondrial NaNature cell biology · 2025Article
- MICU proteins facilitate CaResearch square · 2025Article
- The roles of mitochondria in global and local intracellular calcium signalling.Nature reviews. Molecular cell biology · 2025Review
- Structure of MICU from non-metazoan Dictyostelium discoideum reveals unique characteristics.Communications biology · 2025Article
- Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake.The Journal of clinical investigation · 2025Article
- Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB.Nature communications · 2025Article
- Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1).Life (Basel, Switzerland) · 2025Article
- MICUs protect the heart by regulating mitochondrial calcium.Trends in pharmacological sciences · 2024Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Chen-Wei TsaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Madison X RodriguezDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Anna M Van KeurenDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Charles B PhillipsDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Hannah M ShushunovDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Jessica E LeeDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Anastacia M GarciaDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Amrut V AmbardekarDivision of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Joseph C ClevelandDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Catherine ProenzaDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kathryn C ChatfieldDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ming-Feng TsaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: ming-feng.tsai@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · USHarvard University · US
Funding
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6MPREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1MRegulation of excitability in sinoatrial myocytesR01HL088427 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI PROENZA, CATHERINE · 2008 to 2024
$5.8MAllosteric Modulation of HCN ChannelsR01GM140004 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PROENZA, CATHERINE · 2021 to 2024
$1.7MMolecular mechanisms of the mitochondrial calcium uniporterR01GM129345 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI TSAI, MING-FENG · 2018 to 2022
$1.6MNHLBI NIH HHS R01 HL088427NIDDK NIH HHS P30 DK048520NIGMS NIH HHS R01 GM129345NIGMS NIH HHS R01 GM140004NIGMS NIH HHS T32 GM007635
Abstract
Mitochondrial Ca
Indexed as
CalciumAdenosine TriphosphateAnimalsCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsDisulfidesHumansMiceMitochondrial Membrane Transport ProteinsReactive Oxygen SpeciesAdenosine TriphosphateCalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsDisulfidesMICU1 protein, humanMICU1 protein, mousemitochondrial calcium uniporterMitochondrial Membrane Transport ProteinsReactive Oxygen Speciescalcium channelscardiac pathophysiologycellular metabolismintracellular calcium signalingmembrane-transport mechanismsmitochondrial physiologymitochondrial proteasesorganellar channelsprotein complexes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.