ArticleScience immunology2022
Antigen-specific depletion of CD4
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 53 citations in OpenAlex.
- Reduced CCL/Be-specific CD4+ T cells in CCL3-deficient or peptide-MHCII CAR-T cell-treated mice.JCI insight · 2026Article
- Effects of Lycium barbarum polysaccharide on the activation of pathogenic CD4 + T cells in a mouse model of multiple sclerosis.Neural regeneration research · 2026Article
- T cell-inspired therapeutic delivery platforms: From nanomedicines to cell therapy.Materials today. Bio · 2026Review
- Proteome-scale autoantibody profiling in PSC: Associations with clinical phenotypes and evidence for neuroendocrine deregulations.JHEP reports : innovation in hepatology · 2026Article
- CAR T-Cell Immunotherapy in Neuroautoimmune Diseases: Focus on the Central Nervous System.Biomedicines · 2026Review
- Engineered T cell therapy for the treatment of cardiac fibrosis during chronic phase of myocarditis.Theranostics · 2026Article
- Advancements and expanding applications of CAR-T cell therapy.Frontiers in immunology · 2026Review
- CD47 signaling in aging and age-related diseases: mechanisms, challenges, and therapeutic opportunities.Biogerontology · 2025Review
- Cellular Therapies in Transplantation - Regulatory T Cell Therapies and Virus Specific Therapies.Current transplantation reports · 2025Article
- [Frontier advances in chimeric antigen receptor T cells and chimeric antigen receptor regulatory T cells therapies for autoimmune diseases].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Review
- Post-Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- CAR-engineered cytolytic Tregs reverse pulmonary fibrosis and remodel the fibrotic niche with limited CRS.JCI insight · 2025Article
- A Novel Approach of T Cell Receptor Classification Reveals Dynamic Interactions Amongst Diet, Microbiota, and Host T Cells.Immune network · 2025Review
- Receptor-Mediated SPION Labeling of CD4Nanomaterials (Basel, Switzerland) · 2025Article
- Progressive multiple sclerosis: Evaluating current therapies and exploring future treatment strategies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Kidney immunology from pathophysiology to clinical translation.Nature reviews. Immunology · 2025Review
- Review
- A hierarchy of intestinal antigens instructs the CD4Immunity · 2025Article
- Piezo1 restrains proinflammatory response but is essential in T-cell-mediated immunopathology.Journal of leukocyte biology · 2025Article
- Current advancements in cellular immunotherapy for autoimmune disease.Seminars in immunopathology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Jaeu YiDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4907-3924
Aidan T MillerDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Angela S ArchambaultDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Andrew J JonesDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-0554-3528
Tara R BradstreetDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sravanthi BandlaDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Yu-Sung HsuDivision of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, St. Louis, MO 63105, USA.ORCID 0000-0003-3040-6805
Brian T EdelsonDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-2856-7650
You W ZhouWugen Inc., 4340 Duncan Ave, St. Louis, MO 63110, USA.ORCID 0000-0002-4172-3681
Daved H FremontDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8544-2689
Takeshi EgawaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-7489-1051
Nathan SinghDivision of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, St. Louis, MO 63105, USA.ORCID 0000-0001-5174-0453
Gregory F WuDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0003-3588-0637
Chyi-Song HsiehDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-5976-9250
Washington University in St. Louis · USMoog (United States) · US
Funding
The transcription factor c-MYC in lymphocyte expansion and restriction of stemnessR01AI130152 · NIAID · WASHINGTON UNIVERSITY · PI Takeshi Egawa · 2017 to 2026
$4.6MCAR-T cell treatment of CNS AutoimmunityR01AI165771 · NIAID · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S, WU, GREGORY · 2022 to 2025
$3.4MThe Role of TRPV4 in central nervous system immunity and diseaseR01NS106289 · NINDS · WASHINGTON UNIVERSITY · PI WU, GREGORY · 2018 to 2021
$1.6MMechanisms regulating chimeric antigen receptor T-cell activity in cancerK08CA237740 · NCI · WASHINGTON UNIVERSITY · PI SINGH, NATHAN · 2019 to 2023
$1.2MNCI NIH HHS K08 CA237740NIAID NIH HHS R01 AI130152NIAID NIH HHS R01 AI165771NINDS NIH HHS R01 NS106289
Abstract
Both higher- and lower-affinity self-reactive CD4
Indexed as
Encephalomyelitis, Autoimmune, ExperimentalReceptors, Chimeric AntigenAnimalsAntigensAutoimmunityCD4-Positive T-LymphocytesMicePeptidesReceptors, Antigen, T-CellAntigensPeptidesReceptors, Antigen, T-CellReceptors, Chimeric Antigen
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.