Evidence map›Paper›PMID 36206341›Full record

ArticleScience advances2022

Oncogenic role of a developmentally regulated

Siobhan S Pattwell, Sonali Arora, Nicholas Nuechterlein, Michael Zager, Keith R Loeb, Patrick J Cimino, Nikolas C Holland, Noemi Reche-Ley, Hamid Bolouri, Damian A Almiron Bonnin and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Siobhan S PattwellHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA 98109, USA.ORCID 0000-0003-4434-3139
Sonali AroraHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA 98109, USA.ORCID 0000-0002-6661-3024
Nicholas NuechterleinPaul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-9599-0865
Michael ZagerBrotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-9416-8685
Keith R LoebClinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.ORCID 0000-0002-3305-0261
Patrick J CiminoHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA 98109, USA.ORCID 0000-0003-0441-4502
Nikolas C HollandCenter for Neural Science, New York University, 4 Washington Place, #809, New York, NY 10003, USA.ORCID 0000-0001-9315-7194
Noemi Reche-LeyThe Bush School, 3400 E Harrison St, Seattle, WA 98112, USA.
Hamid BolouriHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA 98109, USA.ORCID 0000-0001-8068-426X
Damian A Almiron BonninHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA 98109, USA.
Frank SzulzewskyHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA 98109, USA.ORCID 0000-0001-5710-9590
Vaishnavi V PhadnisWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0001-8452-8512
Tatsuya OzawaDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Michael J WagnerClinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.ORCID 0000-0002-0753-9282
Michael C HaffnerHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA 98109, USA.
Junyue CaoRockefeller University, 1230 York Ave, New York, NY 10065, USA.
Jay ShendureBrotman Baty Institute for Precision Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-1516-1865
Eric C HollandHuman Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Mailstop C3-168, Seattle, WA 98109, USA.ORCID 0000-0002-3792-7120
Fred Hutch Cancer Center · USNorth Seattle College · USUniversity of Washington · USCornell University · USHarrison Medical Center · USHoward Hughes Medical Institute · USRockefeller University · USSeattle Children's Hospital · USWhitehead Institute for Biomedical Research · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0M
Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
Project 3: Single Cell Measures of Intratumor Diversity for Optimal Breast Cancer TherapyU54CA193461 · NCI · DANA-FARBER CANCER INST · PI HOLLAND, ERIC C., MICHOR, FRANZISKA · 2015 to 2020
$11.2M
Stem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1M
Chromosome Metabolism and Cancer Training GrantT32CA009657 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI EISENMAN, ROBERT NEIL · 1991 to 2020
$7.6M
The Role of Signaling Pathways in Brain Tumors in MiceR01CA100688 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HOLLAND, ERIC C. · 2003 to 2013
$3.8M
Using genetically engineered mouse models of brain tumors to develop therapeutic nanoparticles & biomaterialsR01CA195718 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HOLLAND, ERIC C., HOUGHTON, A MCGARRY · 2016 to 2018
$1.9M
Characterizing an alternatively spliced NTRK2 isoform in development and cancerK22CA258953 · NCI · SEATTLE CHILDREN'S HOSPITAL · PI PATTWELL, SIOBHAN · 2021 to 2023
$637k
CHARACTERIZING AGGRESSIVE GLIOMA COPY NUMBER SUBTYPESK08CA245037 · NCI · UNIVERSITY OF WASHINGTON · PI CIMINO, PATRICK J. · 2020 to 2021
$512k
NCI NIH HHS K08 CA245037NCI NIH HHS K22 CA258953NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA100688NCI NIH HHS R01 CA195718NCI NIH HHS R21 CA223531NCI NIH HHS T32 CA009657NCI NIH HHS U54 CA193461NIA NIH HHS P30 AG066509NIA NIH HHS P50 AG005136NIA NIH HHS U01 AG006781NIDDK NIH HHS U54 DK106829NINDS NIH HHS P50 NS062684
6 · The paper itself

Abstract

Temporally regulated alternative splicing choices are vital for proper development, yet the wrong splice choice may be detrimental. Here, we highlight a previously unidentified role for the neurotrophin receptor splice variant TrkB.T1 in neurodevelopment, embryogenesis, transformation, and oncogenesis across multiple tumor types in humans and mice. TrkB.T1 is the predominant

Identifiers

PMID36206341
PMCPMC9544329
OpenAlexW4303453490

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.